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Novel mechanisms for the removal of strong replication-blocking HMCES- and thiazolidine-DNA adducts in humans

Apurinic/apyrimidinic (AP) sites are DNA lesions created under normal growth conditions that result in cytotoxicity, replication-blocks, and mutations. AP sites are susceptible to β-elimination and are liable to be converted to DNA strand breaks. HMCES (5-hydroxymethylcytosine binding, ES cell speci...

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Detalles Bibliográficos
Autores principales:	Sugimoto, Yohei, Masuda, Yuji, Iwai, Shigenori, Miyake, Yumi, Kanao, Rie, Masutani, Chikahide
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250235/ https://www.ncbi.nlm.nih.gov/pubmed/37021581 http://dx.doi.org/10.1093/nar/gkad246

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