Pluripotency-independent induction of human trophoblast stem cells from fibroblasts

Human trophoblast stem cells (hTSCs) can be derived from embryonic stem cells (hESCs) or be induced from somatic cells by OCT4, SOX2, KLF4 and MYC (OSKM). Here we explore whether the hTSC state can be induced independently of pluripotency, and what are the mechanisms underlying its acquisition. We i...

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Detalles Bibliográficos
Autores principales: Naama, Moriyah, Rahamim, Moran, Zayat, Valery, Sebban, Shulamit, Radwan, Ahmed, Orzech, Dana, Lasry, Rachel, Ifrah, Annael, Jaber, Mohammad, Sabag, Ofra, Yassen, Hazar, Khatib, Areej, Epsztejn-Litman, Silvina, Novoselsky-Persky, Michal, Makedonski, Kirill, Deri, Noy, Goldman-Wohl, Debra, Cedar, Howard, Yagel, Simcha, Eiges, Rachel, Buganim, Yosef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250329/
https://www.ncbi.nlm.nih.gov/pubmed/37291192
http://dx.doi.org/10.1038/s41467-023-39104-1

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