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Origin of minicircular mitochondrial genomes in red algae
Eukaryotic organelle genomes are generally of conserved size and gene content within phylogenetic groups. However, significant variation in genome structure may occur. Here, we report that the Stylonematophyceae red algae contain multipartite circular mitochondrial genomes (i.e., minicircles) which...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250338/ https://www.ncbi.nlm.nih.gov/pubmed/37291154 http://dx.doi.org/10.1038/s41467-023-39084-2 |
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author | Lee, Yongsung Cho, Chung Hyun Noh, Chanyoung Yang, Ji Hyun Park, Seung In Lee, Yu Min West, John A. Bhattacharya, Debashish Jo, Kyubong Yoon, Hwan Su |
author_facet | Lee, Yongsung Cho, Chung Hyun Noh, Chanyoung Yang, Ji Hyun Park, Seung In Lee, Yu Min West, John A. Bhattacharya, Debashish Jo, Kyubong Yoon, Hwan Su |
author_sort | Lee, Yongsung |
collection | PubMed |
description | Eukaryotic organelle genomes are generally of conserved size and gene content within phylogenetic groups. However, significant variation in genome structure may occur. Here, we report that the Stylonematophyceae red algae contain multipartite circular mitochondrial genomes (i.e., minicircles) which encode one or two genes bounded by a specific cassette and a conserved constant region. These minicircles are visualized using fluorescence microscope and scanning electron microscope, proving the circularity. Mitochondrial gene sets are reduced in these highly divergent mitogenomes. Newly generated chromosome-level nuclear genome assembly of Rhodosorus marinus reveals that most mitochondrial ribosomal subunit genes are transferred to the nuclear genome. Hetero-concatemers that resulted from recombination between minicircles and unique gene inventory that is responsible for mitochondrial genome stability may explain how the transition from typical mitochondrial genome to minicircles occurs. Our results offer inspiration on minicircular organelle genome formation and highlight an extreme case of mitochondrial gene inventory reduction. |
format | Online Article Text |
id | pubmed-10250338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102503382023-06-10 Origin of minicircular mitochondrial genomes in red algae Lee, Yongsung Cho, Chung Hyun Noh, Chanyoung Yang, Ji Hyun Park, Seung In Lee, Yu Min West, John A. Bhattacharya, Debashish Jo, Kyubong Yoon, Hwan Su Nat Commun Article Eukaryotic organelle genomes are generally of conserved size and gene content within phylogenetic groups. However, significant variation in genome structure may occur. Here, we report that the Stylonematophyceae red algae contain multipartite circular mitochondrial genomes (i.e., minicircles) which encode one or two genes bounded by a specific cassette and a conserved constant region. These minicircles are visualized using fluorescence microscope and scanning electron microscope, proving the circularity. Mitochondrial gene sets are reduced in these highly divergent mitogenomes. Newly generated chromosome-level nuclear genome assembly of Rhodosorus marinus reveals that most mitochondrial ribosomal subunit genes are transferred to the nuclear genome. Hetero-concatemers that resulted from recombination between minicircles and unique gene inventory that is responsible for mitochondrial genome stability may explain how the transition from typical mitochondrial genome to minicircles occurs. Our results offer inspiration on minicircular organelle genome formation and highlight an extreme case of mitochondrial gene inventory reduction. Nature Publishing Group UK 2023-06-08 /pmc/articles/PMC10250338/ /pubmed/37291154 http://dx.doi.org/10.1038/s41467-023-39084-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lee, Yongsung Cho, Chung Hyun Noh, Chanyoung Yang, Ji Hyun Park, Seung In Lee, Yu Min West, John A. Bhattacharya, Debashish Jo, Kyubong Yoon, Hwan Su Origin of minicircular mitochondrial genomes in red algae |
title | Origin of minicircular mitochondrial genomes in red algae |
title_full | Origin of minicircular mitochondrial genomes in red algae |
title_fullStr | Origin of minicircular mitochondrial genomes in red algae |
title_full_unstemmed | Origin of minicircular mitochondrial genomes in red algae |
title_short | Origin of minicircular mitochondrial genomes in red algae |
title_sort | origin of minicircular mitochondrial genomes in red algae |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250338/ https://www.ncbi.nlm.nih.gov/pubmed/37291154 http://dx.doi.org/10.1038/s41467-023-39084-2 |
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