Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

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Delivering genes to and across the brain vasculature efficiently and specifically across species remains a critical challenge for addressing neurological diseases. We have evolved adeno-associated virus (AAV9) capsids into vectors that transduce brain endothelial cells specifically and efficiently f...

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Detalles Bibliográficos
Autores principales: Chen, Xinhong, Wolfe, Damien A., Bindu, Dhanesh Sivadasan, Zhang, Mengying, Taskin, Naz, Goertsen, David, Shay, Timothy F., Sullivan, Erin E., Huang, Sheng-Fu, Ravindra Kumar, Sripriya, Arokiaraj, Cynthia M., Plattner, Viktor M., Campos, Lillian J., Mich, John K., Monet, Deja, Ngo, Victoria, Ding, Xiaozhe, Omstead, Victoria, Weed, Natalie, Bishaw, Yeme, Gore, Bryan B., Lein, Ed S., Akrami, Athena, Miller, Cory, Levi, Boaz P., Keller, Annika, Ting, Jonathan T., Fox, Andrew S., Eroglu, Cagla, Gradinaru, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250345/
https://www.ncbi.nlm.nih.gov/pubmed/37291094
http://dx.doi.org/10.1038/s41467-023-38582-7

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