acCRISPR: an activity-correction method for improving the accuracy of CRISPR screens

High throughput CRISPR screens are revolutionizing the way scientists unravel the genetic underpinnings of engineered and evolved phenotypes. One of the critical challenges in accurately assessing screening outcomes is accounting for the variability in sgRNA cutting efficiency. Poorly active guides...

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Detalles Bibliográficos
Autores principales: Ramesh, Adithya, Trivedi, Varun, Lee, Sangcheon, Tafrishi, Aida, Schwartz, Cory, Mohseni, Amirsadra, Li, Mengwan, Lonardi, Stefano, Wheeldon, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250353/
https://www.ncbi.nlm.nih.gov/pubmed/37291233
http://dx.doi.org/10.1038/s42003-023-04996-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250353/
https://www.ncbi.nlm.nih.gov/pubmed/37291233
http://dx.doi.org/10.1038/s42003-023-04996-8

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