Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates

Inhibition of eukaryotic initiation factor 4A has been proposed as a strategy to fight pathogens. Rocaglates exhibit the highest specificities among eIF4A inhibitors, but their anti-pathogenic potential has not been comprehensively assessed across eukaryotes. In silico analysis of the substitution p...

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Detalles Bibliográficos
Autores principales: Obermann, Wiebke, Azri, Mohammad Farhan Darin, Konopka, Leonie, Schmidt, Nina, Magari, Francesca, Sherman, Julian, Silva, Liliana M. R., Hermosilla, Carlos, Ludewig, Andreas H., Houhou, Hicham, Haeberlein, Simone, Luo, Mona Yiting, Häcker, Irina, Schetelig, Marc F., Grevelding, Christoph G., Schroeder, Frank C., Lau, Gilbert Sei Kung, Taubert, Anja, Rodriguez, Ana, Heine, Andreas, Yeo, Tiong Chia, Grünweller, Arnold, Taroncher-Oldenburg, Gaspar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250355/
https://www.ncbi.nlm.nih.gov/pubmed/37291191
http://dx.doi.org/10.1038/s41598-023-35765-6

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