Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management

Liquid biopsy approaches offer a promising technology for early and minimally invasive cancer detection. Tumor-educated platelets (TEPs) have emerged as a promising liquid biopsy biosource for the detection of various cancer types. In this study, we processed and analyzed the TEPs collected from 466...

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Autores principales: Antunes-Ferreira, Mafalda, D’Ambrosi, Silvia, Arkani, Mohammad, Post, Edward, In ‘t Veld, Sjors G. J. G., Ramaker, Jip, Zwaan, Kenn, Kucukguzel, Ece Demirel, Wedekind, Laurine E., Griffioen, Arjan W., Oude Egbrink, Mirjam, Kuijpers, Marijke J. E., van den Broek, Daan, Noske, David P., Hartemink, Koen J., Sabrkhany, Siamack, Bahce, Idris, Sol, Nik, Bogaard, Harm-Jan, Koppers-Lalic, Danijela, Best, Myron G., Wurdinger, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250384/
https://www.ncbi.nlm.nih.gov/pubmed/37291189
http://dx.doi.org/10.1038/s41598-023-35818-w
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author Antunes-Ferreira, Mafalda
D’Ambrosi, Silvia
Arkani, Mohammad
Post, Edward
In ‘t Veld, Sjors G. J. G.
Ramaker, Jip
Zwaan, Kenn
Kucukguzel, Ece Demirel
Wedekind, Laurine E.
Griffioen, Arjan W.
Oude Egbrink, Mirjam
Kuijpers, Marijke J. E.
van den Broek, Daan
Noske, David P.
Hartemink, Koen J.
Sabrkhany, Siamack
Bahce, Idris
Sol, Nik
Bogaard, Harm-Jan
Koppers-Lalic, Danijela
Best, Myron G.
Wurdinger, Thomas
author_facet Antunes-Ferreira, Mafalda
D’Ambrosi, Silvia
Arkani, Mohammad
Post, Edward
In ‘t Veld, Sjors G. J. G.
Ramaker, Jip
Zwaan, Kenn
Kucukguzel, Ece Demirel
Wedekind, Laurine E.
Griffioen, Arjan W.
Oude Egbrink, Mirjam
Kuijpers, Marijke J. E.
van den Broek, Daan
Noske, David P.
Hartemink, Koen J.
Sabrkhany, Siamack
Bahce, Idris
Sol, Nik
Bogaard, Harm-Jan
Koppers-Lalic, Danijela
Best, Myron G.
Wurdinger, Thomas
author_sort Antunes-Ferreira, Mafalda
collection PubMed
description Liquid biopsy approaches offer a promising technology for early and minimally invasive cancer detection. Tumor-educated platelets (TEPs) have emerged as a promising liquid biopsy biosource for the detection of various cancer types. In this study, we processed and analyzed the TEPs collected from 466 Non-small Cell Lung Carcinoma (NSCLC) patients and 410 asymptomatic individuals (controls) using the previously established thromboSeq protocol. We developed a novel particle-swarm optimization machine learning algorithm which enabled the selection of an 881 RNA biomarker panel (AUC 0.88). Herein we propose and validate in an independent cohort of samples (n = 558) two approaches for blood samples testing: one with high sensitivity (95% NSCLC detected) and another with high specificity (94% controls detected). Our data explain how TEP-derived spliced RNAs may serve as a biomarker for minimally-invasive clinical blood tests, complement existing imaging tests, and assist the detection and management of lung cancer patients.
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spelling pubmed-102503842023-06-10 Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management Antunes-Ferreira, Mafalda D’Ambrosi, Silvia Arkani, Mohammad Post, Edward In ‘t Veld, Sjors G. J. G. Ramaker, Jip Zwaan, Kenn Kucukguzel, Ece Demirel Wedekind, Laurine E. Griffioen, Arjan W. Oude Egbrink, Mirjam Kuijpers, Marijke J. E. van den Broek, Daan Noske, David P. Hartemink, Koen J. Sabrkhany, Siamack Bahce, Idris Sol, Nik Bogaard, Harm-Jan Koppers-Lalic, Danijela Best, Myron G. Wurdinger, Thomas Sci Rep Article Liquid biopsy approaches offer a promising technology for early and minimally invasive cancer detection. Tumor-educated platelets (TEPs) have emerged as a promising liquid biopsy biosource for the detection of various cancer types. In this study, we processed and analyzed the TEPs collected from 466 Non-small Cell Lung Carcinoma (NSCLC) patients and 410 asymptomatic individuals (controls) using the previously established thromboSeq protocol. We developed a novel particle-swarm optimization machine learning algorithm which enabled the selection of an 881 RNA biomarker panel (AUC 0.88). Herein we propose and validate in an independent cohort of samples (n = 558) two approaches for blood samples testing: one with high sensitivity (95% NSCLC detected) and another with high specificity (94% controls detected). Our data explain how TEP-derived spliced RNAs may serve as a biomarker for minimally-invasive clinical blood tests, complement existing imaging tests, and assist the detection and management of lung cancer patients. Nature Publishing Group UK 2023-06-08 /pmc/articles/PMC10250384/ /pubmed/37291189 http://dx.doi.org/10.1038/s41598-023-35818-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Antunes-Ferreira, Mafalda
D’Ambrosi, Silvia
Arkani, Mohammad
Post, Edward
In ‘t Veld, Sjors G. J. G.
Ramaker, Jip
Zwaan, Kenn
Kucukguzel, Ece Demirel
Wedekind, Laurine E.
Griffioen, Arjan W.
Oude Egbrink, Mirjam
Kuijpers, Marijke J. E.
van den Broek, Daan
Noske, David P.
Hartemink, Koen J.
Sabrkhany, Siamack
Bahce, Idris
Sol, Nik
Bogaard, Harm-Jan
Koppers-Lalic, Danijela
Best, Myron G.
Wurdinger, Thomas
Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management
title Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management
title_full Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management
title_fullStr Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management
title_full_unstemmed Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management
title_short Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management
title_sort tumor-educated platelet blood tests for non-small cell lung cancer detection and management
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250384/
https://www.ncbi.nlm.nih.gov/pubmed/37291189
http://dx.doi.org/10.1038/s41598-023-35818-w
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