Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions

Citrus fruit has long been considered a healthy food, but its role and detailed mechanism in lifespan extension are not clear. Here, by using the nematode C. elegans, we identified that nomilin, a bitter-taste limoloid that is enriched in citrus, significantly extended the animals’ lifespan, healths...

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Detalles Bibliográficos
Autores principales: Fan, Shengjie, Yan, Yingxuan, Xia, Ying, Zhou, Zhenyu, Luo, Lingling, Zhu, Mengnan, Han, Yongli, Yao, Deqiang, Zhang, Lijun, Fang, Minglv, Peng, Lina, Yu, Jing, Liu, Ying, Gao, Xiaoyan, Guan, Huida, Li, Hongli, Wang, Changhong, Wu, Xiaojun, Zhu, Huanhu, Cao, Yu, Huang, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250385/
https://www.ncbi.nlm.nih.gov/pubmed/37291126
http://dx.doi.org/10.1038/s41467-023-39118-9

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