Development of a population pharmacokinetic model of pyrazinamide to guide personalized therapy: impacts of geriatric and diabetes mellitus on clearance

Objectives: This study was performed to develop a population pharmacokinetic model of pyrazinamide for Korean tuberculosis (TB) patients and to explore and identify the influence of demographic and clinical factors, especially geriatric diabetes mellitus (DM), on the pharmacokinetics (PK) of pyrazin...

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Detalles Bibliográficos
Autores principales: Kim, Ryunha, Jayanti, Rannissa Puspita, Lee, Hongyeul, Kim, Hyun-Kuk, Kang, Jiyeon, Park, I-Nae, Kim, Jehun, Oh, Jee Youn, Kim, Hyung Woo, Lee, Heayon, Ghim, Jong-Lyul, Ahn, Sangzin, Long, Nguyen Phuoc, Cho, Yong-Soon, Shin, Jae-Gook, On behalf of the cPMTb
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250603/
https://www.ncbi.nlm.nih.gov/pubmed/37305528
http://dx.doi.org/10.3389/fphar.2023.1116226

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