Intraneuronal accumulation of amyloid-β peptides as the pathomechanism linking autism and its co-morbidities: epilepsy and self-injurious behavior — the hypothesis

Autism spectrum disorder (ASD) is associated with enhanced processing of amyloid-β precursor protein (APP) by secretase-α, higher blood levels of sAPPα and intraneuronal accumulation of N-terminally truncated Aβ peptides in the brain cortex — mainly in the GABAergic neurons expressing parvalbumin —...

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Detalles Bibliográficos
Autores principales: Frackowiak, Janusz, Mazur-Kolecka, Bozena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250631/
https://www.ncbi.nlm.nih.gov/pubmed/37305553
http://dx.doi.org/10.3389/fnmol.2023.1160967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250631/
https://www.ncbi.nlm.nih.gov/pubmed/37305553
http://dx.doi.org/10.3389/fnmol.2023.1160967

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