Single point mutations at the S129 residue of α-synuclein and their effect on structure, aggregation, and neurotoxicity

Parkinson’s disease is an age-related neurological disorder, and the pathology of the disease is linked to different types of aggregates of α-synuclein or alpha-synuclein (aS), which is an intrinsically disordered protein. The C-terminal domain (residues 96–140) of the protein is highly fluctuating...

Descripción completa

Detalles Bibliográficos
Autores principales: Pandit, Esha, Das, Lopamudra, Das, Anoy Kumar, Dolui, Sandip, Saha, Saumen, Pal, Uttam, Mondal, Animesh, Chowdhury, Joydeep, Biswas, Subhas C., Maiti, Nakul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250651/
https://www.ncbi.nlm.nih.gov/pubmed/37304685
http://dx.doi.org/10.3389/fchem.2023.1145877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250651/
https://www.ncbi.nlm.nih.gov/pubmed/37304685
http://dx.doi.org/10.3389/fchem.2023.1145877

Ejemplares similares