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Single point mutations at the S129 residue of α-synuclein and their effect on structure, aggregation, and neurotoxicity

Parkinson’s disease is an age-related neurological disorder, and the pathology of the disease is linked to different types of aggregates of α-synuclein or alpha-synuclein (aS), which is an intrinsically disordered protein. The C-terminal domain (residues 96–140) of the protein is highly fluctuating...

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Detalles Bibliográficos
Autores principales:	Pandit, Esha, Das, Lopamudra, Das, Anoy Kumar, Dolui, Sandip, Saha, Saumen, Pal, Uttam, Mondal, Animesh, Chowdhury, Joydeep, Biswas, Subhas C., Maiti, Nakul C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250651/ https://www.ncbi.nlm.nih.gov/pubmed/37304685 http://dx.doi.org/10.3389/fchem.2023.1145877

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