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Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases

Neurodegenerative diseases have reached alarming numbers in the past decade. Unfortunately, clinical trials testing potential therapeutics have proven futile. In the absence of disease-modifying therapies, physical activity has emerged as the single most accessible lifestyle modification with the po...

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Detalles Bibliográficos
Autores principales: Santiago, Jose A., Potashkin, Judith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250655/
https://www.ncbi.nlm.nih.gov/pubmed/37304072
http://dx.doi.org/10.3389/fnagi.2023.1185671
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author Santiago, Jose A.
Potashkin, Judith A.
author_facet Santiago, Jose A.
Potashkin, Judith A.
author_sort Santiago, Jose A.
collection PubMed
description Neurodegenerative diseases have reached alarming numbers in the past decade. Unfortunately, clinical trials testing potential therapeutics have proven futile. In the absence of disease-modifying therapies, physical activity has emerged as the single most accessible lifestyle modification with the potential to fight off cognitive decline and neurodegeneration. In this review, we discuss findings from epidemiological, clinical, and molecular studies investigating the potential of lifestyle modifications in promoting brain health. We propose an evidence-based multidomain approach that includes physical activity, diet, cognitive training, and sleep hygiene to treat and prevent neurodegenerative diseases.
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spelling pubmed-102506552023-06-10 Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases Santiago, Jose A. Potashkin, Judith A. Front Aging Neurosci Aging Neuroscience Neurodegenerative diseases have reached alarming numbers in the past decade. Unfortunately, clinical trials testing potential therapeutics have proven futile. In the absence of disease-modifying therapies, physical activity has emerged as the single most accessible lifestyle modification with the potential to fight off cognitive decline and neurodegeneration. In this review, we discuss findings from epidemiological, clinical, and molecular studies investigating the potential of lifestyle modifications in promoting brain health. We propose an evidence-based multidomain approach that includes physical activity, diet, cognitive training, and sleep hygiene to treat and prevent neurodegenerative diseases. Frontiers Media S.A. 2023-05-26 /pmc/articles/PMC10250655/ /pubmed/37304072 http://dx.doi.org/10.3389/fnagi.2023.1185671 Text en Copyright © 2023 Santiago and Potashkin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Santiago, Jose A.
Potashkin, Judith A.
Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases
title Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases
title_full Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases
title_fullStr Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases
title_full_unstemmed Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases
title_short Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases
title_sort physical activity and lifestyle modifications in the treatment of neurodegenerative diseases
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250655/
https://www.ncbi.nlm.nih.gov/pubmed/37304072
http://dx.doi.org/10.3389/fnagi.2023.1185671
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