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Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia
BACKGROUND: Respiratory infections are one of the most common comorbidities identified in hospitalized patients. The coronavirus disease 2019 (COVID-19) pandemic greatly impacted healthcare systems, including acute cardiac services. AIM: This study aimed to describe the echocardiographic findings of...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250739/ https://www.ncbi.nlm.nih.gov/pubmed/37304946 http://dx.doi.org/10.3389/fcvm.2023.1134601 |
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author | Abohamr, Samah I. Abazid, Rami M. Alhumaid, Mohammed K. Abdulrahim, Abubaker E. Aldossari, Mubarak A. Khedr, Lamiaa Werida, Rehab H. Alkheledan, Haifa S. Aleid, Yazeed S. Abdelhamid, Sara W. Al Mefarrej, Abdulmohsen Abdelhamid, Ahmed W. Alaboud, Mohammad Hasan Alhasan, Omar T. Gomaa, Hanem M. Elsheikh, Eman |
author_facet | Abohamr, Samah I. Abazid, Rami M. Alhumaid, Mohammed K. Abdulrahim, Abubaker E. Aldossari, Mubarak A. Khedr, Lamiaa Werida, Rehab H. Alkheledan, Haifa S. Aleid, Yazeed S. Abdelhamid, Sara W. Al Mefarrej, Abdulmohsen Abdelhamid, Ahmed W. Alaboud, Mohammad Hasan Alhasan, Omar T. Gomaa, Hanem M. Elsheikh, Eman |
author_sort | Abohamr, Samah I. |
collection | PubMed |
description | BACKGROUND: Respiratory infections are one of the most common comorbidities identified in hospitalized patients. The coronavirus disease 2019 (COVID-19) pandemic greatly impacted healthcare systems, including acute cardiac services. AIM: This study aimed to describe the echocardiographic findings of patients with COVID-19 infections and their correlations with inflammatory biomarkers, disease severity, and clinical outcomes. METHODS: This observational study was conducted between June 2021 and July 2022. The analysis included all patients diagnosed with COVID-19 who had transthoracic echocardiographic (TTE) scans within 72 h of admission. RESULTS: The enrolled patients had a mean age of 55.6 ± 14.7 years, and 66.1% were male. Of the 490 enrolled patients, 203 (41.4%) were admitted to the intensive care unit (ICU). Pre-ICU TTE findings showed significantly higher incidence right ventricular dysfunction (28 [13.8%] vs. 23 [8.0%]; P = 0.04) and left ventricular (LV) regional wall motion abnormalities (55 [27.1%] vs. 29 [10.1%]; p < 0.001) in ICU patients compared to non-ICU patients. In-hospital mortality was 11 (2.2%), all deaths of ICU patients. The most sensitive predictors of ICU admission (p < 0.05): cardiac troponin I level (area under the curve [AUC] = 0.733), followed by hs-CRP (AUC = 0.620), creatine kinase-MB (AUC = 0.617), D-dimer (AUC = 0.599), and lactate dehydrogenase (AUC = 0.567). Binary logistic regression showed that reduced LV ejection fraction (LVEF), elevated pulmonary artery systolic pressure, and dilated right ventricle were echocardiographic predictors of poor outcomes (p < 0.05). CONCLUSION: Echocardiography is a valuable tool in assessing admitted patients with COVID-19. Lower LVEF, pulmonary hypertension, higher D-dimer, C-reactive protein, and B-type natriuretic peptide levels were predictors of poor outcomes. |
format | Online Article Text |
id | pubmed-10250739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102507392023-06-10 Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia Abohamr, Samah I. Abazid, Rami M. Alhumaid, Mohammed K. Abdulrahim, Abubaker E. Aldossari, Mubarak A. Khedr, Lamiaa Werida, Rehab H. Alkheledan, Haifa S. Aleid, Yazeed S. Abdelhamid, Sara W. Al Mefarrej, Abdulmohsen Abdelhamid, Ahmed W. Alaboud, Mohammad Hasan Alhasan, Omar T. Gomaa, Hanem M. Elsheikh, Eman Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Respiratory infections are one of the most common comorbidities identified in hospitalized patients. The coronavirus disease 2019 (COVID-19) pandemic greatly impacted healthcare systems, including acute cardiac services. AIM: This study aimed to describe the echocardiographic findings of patients with COVID-19 infections and their correlations with inflammatory biomarkers, disease severity, and clinical outcomes. METHODS: This observational study was conducted between June 2021 and July 2022. The analysis included all patients diagnosed with COVID-19 who had transthoracic echocardiographic (TTE) scans within 72 h of admission. RESULTS: The enrolled patients had a mean age of 55.6 ± 14.7 years, and 66.1% were male. Of the 490 enrolled patients, 203 (41.4%) were admitted to the intensive care unit (ICU). Pre-ICU TTE findings showed significantly higher incidence right ventricular dysfunction (28 [13.8%] vs. 23 [8.0%]; P = 0.04) and left ventricular (LV) regional wall motion abnormalities (55 [27.1%] vs. 29 [10.1%]; p < 0.001) in ICU patients compared to non-ICU patients. In-hospital mortality was 11 (2.2%), all deaths of ICU patients. The most sensitive predictors of ICU admission (p < 0.05): cardiac troponin I level (area under the curve [AUC] = 0.733), followed by hs-CRP (AUC = 0.620), creatine kinase-MB (AUC = 0.617), D-dimer (AUC = 0.599), and lactate dehydrogenase (AUC = 0.567). Binary logistic regression showed that reduced LV ejection fraction (LVEF), elevated pulmonary artery systolic pressure, and dilated right ventricle were echocardiographic predictors of poor outcomes (p < 0.05). CONCLUSION: Echocardiography is a valuable tool in assessing admitted patients with COVID-19. Lower LVEF, pulmonary hypertension, higher D-dimer, C-reactive protein, and B-type natriuretic peptide levels were predictors of poor outcomes. Frontiers Media S.A. 2023-05-26 /pmc/articles/PMC10250739/ /pubmed/37304946 http://dx.doi.org/10.3389/fcvm.2023.1134601 Text en © 2023 Abohamr, Abazid, Alhumaid, Abdulrahim, Aldossari, Khedr, Werida, Alkheledan, Aleid, Abdelhamid, AI Mefarrej, Abdelhamid, Alaboud, Alhasan, Gomaa and Elsheikh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Abohamr, Samah I. Abazid, Rami M. Alhumaid, Mohammed K. Abdulrahim, Abubaker E. Aldossari, Mubarak A. Khedr, Lamiaa Werida, Rehab H. Alkheledan, Haifa S. Aleid, Yazeed S. Abdelhamid, Sara W. Al Mefarrej, Abdulmohsen Abdelhamid, Ahmed W. Alaboud, Mohammad Hasan Alhasan, Omar T. Gomaa, Hanem M. Elsheikh, Eman Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia |
title | Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia |
title_full | Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia |
title_fullStr | Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia |
title_full_unstemmed | Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia |
title_short | Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia |
title_sort | association between echocardiographic features and inflammatory biomarkers with clinical outcomes in covid-19 patients in saudi arabia |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250739/ https://www.ncbi.nlm.nih.gov/pubmed/37304946 http://dx.doi.org/10.3389/fcvm.2023.1134601 |
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