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Factors affecting the outcomes in patients with acute respiratory distress syndrome in a tertiary care setting

PURPOSE: The clinical profile and factors affecting outcomes in acute respiratory distress syndrome (ARDS) from adequately sample-sized Indian studies are still lacking. We aimed to investigate the clinical profile, treatment pattern, outcomes; and to assess factors affecting non-recovery in ARDS pa...

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Autores principales: Rashid, Muhammed, Ramakrishnan, Manasvini, Muthu, Deepa Sudalai, Chandran, Viji Pulikkel, Thunga, Girish, Kunhikatta, Vijayanarayana, Shanbhag, Vishal, Acharya, Raviraja V., Nair, Sreedharan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. on behalf of INDIACLEN. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250822/
https://www.ncbi.nlm.nih.gov/pubmed/37309426
http://dx.doi.org/10.1016/j.cegh.2022.100972
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author Rashid, Muhammed
Ramakrishnan, Manasvini
Muthu, Deepa Sudalai
Chandran, Viji Pulikkel
Thunga, Girish
Kunhikatta, Vijayanarayana
Shanbhag, Vishal
Acharya, Raviraja V.
Nair, Sreedharan
author_facet Rashid, Muhammed
Ramakrishnan, Manasvini
Muthu, Deepa Sudalai
Chandran, Viji Pulikkel
Thunga, Girish
Kunhikatta, Vijayanarayana
Shanbhag, Vishal
Acharya, Raviraja V.
Nair, Sreedharan
author_sort Rashid, Muhammed
collection PubMed
description PURPOSE: The clinical profile and factors affecting outcomes in acute respiratory distress syndrome (ARDS) from adequately sample-sized Indian studies are still lacking. We aimed to investigate the clinical profile, treatment pattern, outcomes; and to assess factors affecting non-recovery in ARDS patients. PATIENTS AND METHODS: A retrospective observational study was conducted among adult ARDS patients admitted during five year period (January 2014–December 2018) in a South Indian tertiary care setting. The relevant data were collected from the medical records to the data collection form. The univariate and multivariate logistic regression analyses were conducted to identify the predictors of outcomes using SPSS v20. RESULTS: A total of 857 participants including 496 males and 361 females with a mean age of 46.86 ± 15.81 years were included in this study. Fever (70.9%), crepitation (58.3%), breathlessness (56.9%), and cough (45%) were the major clinical presentation. Hypertension (25.2%), kidney disease (23.8%), and diabetes (22.3%) were the major comorbidities; and sepsis (37.6%), pneumonia (33.3%), and septic shock (27.5%) were the major etiological factors observed. Antibiotics and steroids were administered to 97.9% and 52.3% of the population, respectively. The recovery rate was 47.49%. The patients with scrub typhus, dengue, pancreatitis, and oxygen supplementation had significantly lower mortality. The factors such as advanced age, sepsis, septic shock, liver diseases, and ventilation requirements were observed to be the independent predictors of non-recovery in ARDS patients. CONCLUSION: A comparable recovery rate was observed in our population. Advanced age, sepsis, septic shock, liver diseases, and ventilation requirements were the independent predictors of non-recovery.
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spelling pubmed-102508222023-06-09 Factors affecting the outcomes in patients with acute respiratory distress syndrome in a tertiary care setting Rashid, Muhammed Ramakrishnan, Manasvini Muthu, Deepa Sudalai Chandran, Viji Pulikkel Thunga, Girish Kunhikatta, Vijayanarayana Shanbhag, Vishal Acharya, Raviraja V. Nair, Sreedharan Clin Epidemiol Glob Health Article PURPOSE: The clinical profile and factors affecting outcomes in acute respiratory distress syndrome (ARDS) from adequately sample-sized Indian studies are still lacking. We aimed to investigate the clinical profile, treatment pattern, outcomes; and to assess factors affecting non-recovery in ARDS patients. PATIENTS AND METHODS: A retrospective observational study was conducted among adult ARDS patients admitted during five year period (January 2014–December 2018) in a South Indian tertiary care setting. The relevant data were collected from the medical records to the data collection form. The univariate and multivariate logistic regression analyses were conducted to identify the predictors of outcomes using SPSS v20. RESULTS: A total of 857 participants including 496 males and 361 females with a mean age of 46.86 ± 15.81 years were included in this study. Fever (70.9%), crepitation (58.3%), breathlessness (56.9%), and cough (45%) were the major clinical presentation. Hypertension (25.2%), kidney disease (23.8%), and diabetes (22.3%) were the major comorbidities; and sepsis (37.6%), pneumonia (33.3%), and septic shock (27.5%) were the major etiological factors observed. Antibiotics and steroids were administered to 97.9% and 52.3% of the population, respectively. The recovery rate was 47.49%. The patients with scrub typhus, dengue, pancreatitis, and oxygen supplementation had significantly lower mortality. The factors such as advanced age, sepsis, septic shock, liver diseases, and ventilation requirements were observed to be the independent predictors of non-recovery in ARDS patients. CONCLUSION: A comparable recovery rate was observed in our population. Advanced age, sepsis, septic shock, liver diseases, and ventilation requirements were the independent predictors of non-recovery. The Authors. Published by Elsevier B.V. on behalf of INDIACLEN. 2022 2022-01-18 /pmc/articles/PMC10250822/ /pubmed/37309426 http://dx.doi.org/10.1016/j.cegh.2022.100972 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Rashid, Muhammed
Ramakrishnan, Manasvini
Muthu, Deepa Sudalai
Chandran, Viji Pulikkel
Thunga, Girish
Kunhikatta, Vijayanarayana
Shanbhag, Vishal
Acharya, Raviraja V.
Nair, Sreedharan
Factors affecting the outcomes in patients with acute respiratory distress syndrome in a tertiary care setting
title Factors affecting the outcomes in patients with acute respiratory distress syndrome in a tertiary care setting
title_full Factors affecting the outcomes in patients with acute respiratory distress syndrome in a tertiary care setting
title_fullStr Factors affecting the outcomes in patients with acute respiratory distress syndrome in a tertiary care setting
title_full_unstemmed Factors affecting the outcomes in patients with acute respiratory distress syndrome in a tertiary care setting
title_short Factors affecting the outcomes in patients with acute respiratory distress syndrome in a tertiary care setting
title_sort factors affecting the outcomes in patients with acute respiratory distress syndrome in a tertiary care setting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250822/
https://www.ncbi.nlm.nih.gov/pubmed/37309426
http://dx.doi.org/10.1016/j.cegh.2022.100972
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