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Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo

Pancreatic ductal adenocarcinoma (PDAC) remains one of the human cancers with the poorest prognosis. Interestingly, we found that mitochondrial respiration in primary human PDAC cells depends mainly on the fatty acid oxidation (FAO) to meet basic energy requirements. Therefore, we treated PDAC cells...

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Detalles Bibliográficos
Autores principales:	Reyes-Castellanos, Gabriela, Abdel Hadi, Nadine, Gallardo-Arriaga, Scarlett, Masoud, Rawand, Garcia, Julie, Lac, Sophie, El Kaoutari, Abdessamad, Gicquel, Tristan, Planque, Mélanie, Fendt, Sarah-Maria, Linares, Laetitia Karine, Gayet, Odile, Guillaumond, Fabienne, Dusetti, Nelson, Iovanna, Juan, Carrier, Alice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250830/ https://www.ncbi.nlm.nih.gov/pubmed/37305702 http://dx.doi.org/10.1016/j.isci.2023.106899

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