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The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis

BACKGROUND: Adverse childhood experiences have been linked to increased multimorbidity, with physical and mental health consequences throughout life. Chronic pain is often associated with mood disorders, such as major depressive disorder (MDD); both have been linked to adverse childhood experiences....

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Detalles Bibliográficos
Autores principales: Antoniou, Georgia, Lambourg, Emilie, Steele, J. Douglas, Colvin, Lesley A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251130/
https://www.ncbi.nlm.nih.gov/pubmed/37087334
http://dx.doi.org/10.1016/j.bja.2023.03.008
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author Antoniou, Georgia
Lambourg, Emilie
Steele, J. Douglas
Colvin, Lesley A.
author_facet Antoniou, Georgia
Lambourg, Emilie
Steele, J. Douglas
Colvin, Lesley A.
author_sort Antoniou, Georgia
collection PubMed
description BACKGROUND: Adverse childhood experiences have been linked to increased multimorbidity, with physical and mental health consequences throughout life. Chronic pain is often associated with mood disorders, such as major depressive disorder (MDD); both have been linked to adverse childhood experiences. It is unclear how the effect of adverse childhood experiences on neural processing impacts on vulnerability to chronic pain, MDD, or both, and whether there are shared mechanisms. We aimed to assess evidence for central neural changes associated with adverse childhood experiences in subjects with chronic pain, MDD, or both using systematic review and meta-analysis. METHODS: Electronic databases were systematically searched for neuroimaging studies of adverse childhood experiences, with chronic pain, MDD, or both. Two independent reviewers screened title, abstracts, and full text, and assessed quality. After extraction of neuroimaging data, activation likelihood estimate meta-analysis was performed to identify significant brain regions associated with these comorbidities. RESULTS: Forty-nine of 2414 studies were eligible, of which 43 investigated adverse childhood experiences and MDD and six investigated adverse childhood experiences and chronic pain. None investigated adverse childhood experiences, chronic pain, and MDD together. Functional and structural brain abnormalities were identified in the superior frontal, lingual gyrus, hippocampus, insula, putamen, superior temporal, inferior temporal gyrus, and anterior cerebellum in patients with MDD exposed to adverse childhood experiences. In addition, brain function abnormalities were identified for patients with MDD or chronic pain and exposure to adverse childhood experiences in the cingulate gyrus, inferior parietal lobule, and precuneus in task-based functional MRI studies. CONCLUSIONS: We found that adverse childhood experiences exposure can result in different functional and structural brain alterations in adults with MDD or chronic pain compared with those without adverse childhood experiences. SYSTEMATIC REVIEW PROTOCOL: PROSPERO CRD42021233989.
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spelling pubmed-102511302023-06-10 The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis Antoniou, Georgia Lambourg, Emilie Steele, J. Douglas Colvin, Lesley A. Br J Anaesth Review Article BACKGROUND: Adverse childhood experiences have been linked to increased multimorbidity, with physical and mental health consequences throughout life. Chronic pain is often associated with mood disorders, such as major depressive disorder (MDD); both have been linked to adverse childhood experiences. It is unclear how the effect of adverse childhood experiences on neural processing impacts on vulnerability to chronic pain, MDD, or both, and whether there are shared mechanisms. We aimed to assess evidence for central neural changes associated with adverse childhood experiences in subjects with chronic pain, MDD, or both using systematic review and meta-analysis. METHODS: Electronic databases were systematically searched for neuroimaging studies of adverse childhood experiences, with chronic pain, MDD, or both. Two independent reviewers screened title, abstracts, and full text, and assessed quality. After extraction of neuroimaging data, activation likelihood estimate meta-analysis was performed to identify significant brain regions associated with these comorbidities. RESULTS: Forty-nine of 2414 studies were eligible, of which 43 investigated adverse childhood experiences and MDD and six investigated adverse childhood experiences and chronic pain. None investigated adverse childhood experiences, chronic pain, and MDD together. Functional and structural brain abnormalities were identified in the superior frontal, lingual gyrus, hippocampus, insula, putamen, superior temporal, inferior temporal gyrus, and anterior cerebellum in patients with MDD exposed to adverse childhood experiences. In addition, brain function abnormalities were identified for patients with MDD or chronic pain and exposure to adverse childhood experiences in the cingulate gyrus, inferior parietal lobule, and precuneus in task-based functional MRI studies. CONCLUSIONS: We found that adverse childhood experiences exposure can result in different functional and structural brain alterations in adults with MDD or chronic pain compared with those without adverse childhood experiences. SYSTEMATIC REVIEW PROTOCOL: PROSPERO CRD42021233989. Elsevier 2023-06 2023-04-21 /pmc/articles/PMC10251130/ /pubmed/37087334 http://dx.doi.org/10.1016/j.bja.2023.03.008 Text en Crown Copyright © 2023 Published by Elsevier Ltd on behalf of British Journal of Anaesthesia. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Antoniou, Georgia
Lambourg, Emilie
Steele, J. Douglas
Colvin, Lesley A.
The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis
title The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis
title_full The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis
title_fullStr The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis
title_full_unstemmed The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis
title_short The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis
title_sort effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251130/
https://www.ncbi.nlm.nih.gov/pubmed/37087334
http://dx.doi.org/10.1016/j.bja.2023.03.008
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