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Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity

Tau-mediated toxicity is associated with cognitive decline and Alzheimer’s disease (AD) progression. In particular, tau post-translational modifications (PTMs) are thought to generate aberrant tau species resulting in neuronal dysfunction. Despite being well characterized in postmortem AD brain, it...

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Detalles Bibliográficos
Autores principales:	Opland, Carli K., Bryan, Miles R., Harris, Braxton, McGillion-Moore, Jake, Tian, Xu, Chen, Youjun, Itano, Michelle S., Diering, Graham H., Meeker, Rick B., Cohen, Todd J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251131/ https://www.ncbi.nlm.nih.gov/pubmed/37305696 http://dx.doi.org/10.1016/j.isci.2023.106905

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