C. albicans UME7 deletion does not have major impacts on white opaque switching, filamentation, or virulence

C. albicans is the most prevalent human fungal pathogen, and can be especially dangerous to immunocompromised individuals. One key aspect of C. albicans virulence is morphological plasticity. C. albicans can undergo a number of distinct morphological changes and these changes are controlled by complex transcriptional networks. The transcription factor Ume6 is an important member of these networks, playing an essential role mediating filamentation. C. albicans , however encodes a second UME6 homolog, UME7 . UME7 is highly conserved in the CTG fungal clade, but the role of UME7 in C. albicans biology is unknown. Here we truncate and delete C. albicans UME7 . We find Ume7 is dispensable for growth and filamentation. We also find that deletion does not have major consequences on virulence or white opaque switching. Our results suggest that under standard laboratory conditions deletion of UME7 does not have large effects on C. albicans phenotype leaving its role in C. albicans biology undefined.