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Predictors of Mortality in Adults With Sickle Cell Disease Admitted to the Intensive Care Unit in King Saud Medical City, Saudi Arabia

Background Sickle cell disease (SCD) is the most common genetic blood disorder in Saudi Arabia. A limited number of studies have been conducted on SCD patients regarding their intensive care unit (ICU) admissions. We aimed to identify the cause of ICU admission in SCD patients and to identify predic...

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Autores principales: Alhaj Zeen, Mustafa, Mohamed, Nourhan E, Mady, Ahmed F, Alamri, Mohammed M, Alshammari, Saitah, Alshebaily, Abdulilh K, Hijazi, Huda, Hegazy, Asmaa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251455/
https://www.ncbi.nlm.nih.gov/pubmed/37303370
http://dx.doi.org/10.7759/cureus.38817
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author Alhaj Zeen, Mustafa
Mohamed, Nourhan E
Mady, Ahmed F
Alamri, Mohammed M
Alshammari, Saitah
Alshebaily, Abdulilh K
Hijazi, Huda
Hegazy, Asmaa
author_facet Alhaj Zeen, Mustafa
Mohamed, Nourhan E
Mady, Ahmed F
Alamri, Mohammed M
Alshammari, Saitah
Alshebaily, Abdulilh K
Hijazi, Huda
Hegazy, Asmaa
author_sort Alhaj Zeen, Mustafa
collection PubMed
description Background Sickle cell disease (SCD) is the most common genetic blood disorder in Saudi Arabia. A limited number of studies have been conducted on SCD patients regarding their intensive care unit (ICU) admissions. We aimed to identify the cause of ICU admission in SCD patients and to identify predictors of mortality. Methodology We identified 64 patients with SCD, aged 14 years and older, who were admitted to the ICU of King Saud Medical City, Riyadh, Kingdom of Saudi Arabia, from January 1, 2017, to December 31, 2020. Results Acute chest syndrome was the most frequent primary diagnosis for ICU admission in 29 (45.3%) patients followed by vaso-occlusive crisis in 23 (35.9%) patients. Pregnancy in eight (12.5%) patients was the most prevalent co-existing condition. The median age was 29 years, with males comprising 45.3% and females comprising 54.7% of the study population. Arterial blood gas pH less than 7.2 on ICU admission (p= <0.001), hemodialysis support (p= 0.049), the use of vasopressors (p= 0.016), intubation (p= <0.001), and being intubated within the first 24 hours of ICU stay (p= 0.04) had a statistically significant association with mortality at ICU discharge out of all the variables tested. Mortality on ICU discharge was 7 (10.9%). Conclusion This was a retrospective study carried out in King Saud Medical City. Comparing the results of the study to those of similar ones conducted around the world revealed a low SCD ICU mortality rate. This low mortality may be a result of improved overall ICU care. We recommend a multi-center, prospective study in future.
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spelling pubmed-102514552023-06-10 Predictors of Mortality in Adults With Sickle Cell Disease Admitted to the Intensive Care Unit in King Saud Medical City, Saudi Arabia Alhaj Zeen, Mustafa Mohamed, Nourhan E Mady, Ahmed F Alamri, Mohammed M Alshammari, Saitah Alshebaily, Abdulilh K Hijazi, Huda Hegazy, Asmaa Cureus Internal Medicine Background Sickle cell disease (SCD) is the most common genetic blood disorder in Saudi Arabia. A limited number of studies have been conducted on SCD patients regarding their intensive care unit (ICU) admissions. We aimed to identify the cause of ICU admission in SCD patients and to identify predictors of mortality. Methodology We identified 64 patients with SCD, aged 14 years and older, who were admitted to the ICU of King Saud Medical City, Riyadh, Kingdom of Saudi Arabia, from January 1, 2017, to December 31, 2020. Results Acute chest syndrome was the most frequent primary diagnosis for ICU admission in 29 (45.3%) patients followed by vaso-occlusive crisis in 23 (35.9%) patients. Pregnancy in eight (12.5%) patients was the most prevalent co-existing condition. The median age was 29 years, with males comprising 45.3% and females comprising 54.7% of the study population. Arterial blood gas pH less than 7.2 on ICU admission (p= <0.001), hemodialysis support (p= 0.049), the use of vasopressors (p= 0.016), intubation (p= <0.001), and being intubated within the first 24 hours of ICU stay (p= 0.04) had a statistically significant association with mortality at ICU discharge out of all the variables tested. Mortality on ICU discharge was 7 (10.9%). Conclusion This was a retrospective study carried out in King Saud Medical City. Comparing the results of the study to those of similar ones conducted around the world revealed a low SCD ICU mortality rate. This low mortality may be a result of improved overall ICU care. We recommend a multi-center, prospective study in future. Cureus 2023-05-10 /pmc/articles/PMC10251455/ /pubmed/37303370 http://dx.doi.org/10.7759/cureus.38817 Text en Copyright © 2023, Alhaj Zeen et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Alhaj Zeen, Mustafa
Mohamed, Nourhan E
Mady, Ahmed F
Alamri, Mohammed M
Alshammari, Saitah
Alshebaily, Abdulilh K
Hijazi, Huda
Hegazy, Asmaa
Predictors of Mortality in Adults With Sickle Cell Disease Admitted to the Intensive Care Unit in King Saud Medical City, Saudi Arabia
title Predictors of Mortality in Adults With Sickle Cell Disease Admitted to the Intensive Care Unit in King Saud Medical City, Saudi Arabia
title_full Predictors of Mortality in Adults With Sickle Cell Disease Admitted to the Intensive Care Unit in King Saud Medical City, Saudi Arabia
title_fullStr Predictors of Mortality in Adults With Sickle Cell Disease Admitted to the Intensive Care Unit in King Saud Medical City, Saudi Arabia
title_full_unstemmed Predictors of Mortality in Adults With Sickle Cell Disease Admitted to the Intensive Care Unit in King Saud Medical City, Saudi Arabia
title_short Predictors of Mortality in Adults With Sickle Cell Disease Admitted to the Intensive Care Unit in King Saud Medical City, Saudi Arabia
title_sort predictors of mortality in adults with sickle cell disease admitted to the intensive care unit in king saud medical city, saudi arabia
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251455/
https://www.ncbi.nlm.nih.gov/pubmed/37303370
http://dx.doi.org/10.7759/cureus.38817
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