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Transition Metal-Free Regioselective Phosphonation of Pyridines: Scope and Mechanism

[Image: see text] Regioselective phosphonation of pyridines is an interesting transformation in synthesis and medicinal chemistry. We report herein a metal-free approach enabling access to various 4-phosphonated pyridines. The method consists of simply activating the pyridine ring with a Lewis acid...

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Detalles Bibliográficos
Autores principales: Quint, Valentin, Van Nguyen, Thi Hong, Mathieu, Gary, Chelli, Saloua, Breugst, Martin, Lohier, Jean-François, Gaumont, Annie-Claude, Lakhdar, Sami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251503/
https://www.ncbi.nlm.nih.gov/pubmed/37303502
http://dx.doi.org/10.1021/acsorginorgau.2c00055

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