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Tandem Dearomatization/Enantioselective Allylic Alkylation of Pyridines

[Image: see text] Herein, we report a multistep one-pot reaction of substituted pyridines leading to N-protected tetrahydropyridines with outstanding enantioselectivity (up to 97% ee). An iridium(I)-catalyzed dearomative 1,2-hydrosilylation of pyridines enables the use of N-silyl enamines as a new t...

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Detalles Bibliográficos
Autores principales:	Greßies, Steffen, Süße, Lars, Casselman, Tyler, Stoltz, Brian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251512/ https://www.ncbi.nlm.nih.gov/pubmed/37212659 http://dx.doi.org/10.1021/jacs.3c02470

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