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Predisposing factors for Hoffa’s fat pad syndrome: a systematic review

BACKGROUND: Hoffa’s fat pad syndrome has been defined as impingement of Hoffa’s fat pad, leading to oedema and fibrosis. The primary aim of this systematic review was to identify morphological differences in Hoffa’s fat pad between patients with and without Hoffa’s fat pad syndrome, evaluating them...

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Autores principales: Abelleyra Lastoria, Diego Agustín, Benny, Clerin Kulangara, Hing, Caroline Blanca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251569/
https://www.ncbi.nlm.nih.gov/pubmed/37296488
http://dx.doi.org/10.1186/s43019-023-00192-4
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author Abelleyra Lastoria, Diego Agustín
Benny, Clerin Kulangara
Hing, Caroline Blanca
author_facet Abelleyra Lastoria, Diego Agustín
Benny, Clerin Kulangara
Hing, Caroline Blanca
author_sort Abelleyra Lastoria, Diego Agustín
collection PubMed
description BACKGROUND: Hoffa’s fat pad syndrome has been defined as impingement of Hoffa’s fat pad, leading to oedema and fibrosis. The primary aim of this systematic review was to identify morphological differences in Hoffa’s fat pad between patients with and without Hoffa’s fat pad syndrome, evaluating them as risk factors predisposing to its development. The secondary aim was to summarize and evaluate current evidence pertaining to the management of Hoffa’s fat pad syndrome. MATERIALS AND METHODS: The protocol for this review was prospectively registered (PROSPERO registration: CRD42022357036). Electronic databases, currently registered studies, conference proceedings and the reference lists of included studies were searched. All studies evaluating differences in Hoffa’s fat pad anatomy under imaging between patients with and without Hoffa’s fat pad syndrome were included, as well as those exploring epidemiological factors predisposing to its development (ethnicity, employment status, sex, age and BMI), and studies reporting on the effect of treatment on Hoffa’s fat pad morphology. RESULTS: A total of 3871 records were screened. Twenty one articles satisfied the inclusion criteria, evaluating 3603 knees of 3518 patients. Patella alta, increased tibial tubercle-tibial groove distance, and increased trochlear angle were found to predispose the development of Hoffa’s fat pad syndrome. Trochlear inclination, sulcus angle, patient age and BMI were not associated with this condition. The link between Hoffa’s fat pad syndrome and ethnicity, employment, patellar alignment, Hoffa’s fat pad composition, physical activity and other pathological processes cannot be established due to lack of evidence. No studies reporting on treatment for Hoffa’s fat pad syndrome were identified. Though weight loss and gene therapy may provide symptomatic relief, further research is required to corroborate these claims. CONCLUSION: Current evidence suggests that high patellar height, TT-TG distance, and trochlear angle predispose the development of Hoffa’s fat pad syndrome. In addition, trochlear inclination, sulcus angle, patient age and BMI do not seem to be associated with this condition. Further research should explore the link between Hoffa’s fat pad syndrome and sport as well as other conditions pertaining to the knee. In addition, further study evaluating treatment approaches for Hoffa’s fat pad syndrome is required.
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spelling pubmed-102515692023-06-10 Predisposing factors for Hoffa’s fat pad syndrome: a systematic review Abelleyra Lastoria, Diego Agustín Benny, Clerin Kulangara Hing, Caroline Blanca Knee Surg Relat Res Review Article BACKGROUND: Hoffa’s fat pad syndrome has been defined as impingement of Hoffa’s fat pad, leading to oedema and fibrosis. The primary aim of this systematic review was to identify morphological differences in Hoffa’s fat pad between patients with and without Hoffa’s fat pad syndrome, evaluating them as risk factors predisposing to its development. The secondary aim was to summarize and evaluate current evidence pertaining to the management of Hoffa’s fat pad syndrome. MATERIALS AND METHODS: The protocol for this review was prospectively registered (PROSPERO registration: CRD42022357036). Electronic databases, currently registered studies, conference proceedings and the reference lists of included studies were searched. All studies evaluating differences in Hoffa’s fat pad anatomy under imaging between patients with and without Hoffa’s fat pad syndrome were included, as well as those exploring epidemiological factors predisposing to its development (ethnicity, employment status, sex, age and BMI), and studies reporting on the effect of treatment on Hoffa’s fat pad morphology. RESULTS: A total of 3871 records were screened. Twenty one articles satisfied the inclusion criteria, evaluating 3603 knees of 3518 patients. Patella alta, increased tibial tubercle-tibial groove distance, and increased trochlear angle were found to predispose the development of Hoffa’s fat pad syndrome. Trochlear inclination, sulcus angle, patient age and BMI were not associated with this condition. The link between Hoffa’s fat pad syndrome and ethnicity, employment, patellar alignment, Hoffa’s fat pad composition, physical activity and other pathological processes cannot be established due to lack of evidence. No studies reporting on treatment for Hoffa’s fat pad syndrome were identified. Though weight loss and gene therapy may provide symptomatic relief, further research is required to corroborate these claims. CONCLUSION: Current evidence suggests that high patellar height, TT-TG distance, and trochlear angle predispose the development of Hoffa’s fat pad syndrome. In addition, trochlear inclination, sulcus angle, patient age and BMI do not seem to be associated with this condition. Further research should explore the link between Hoffa’s fat pad syndrome and sport as well as other conditions pertaining to the knee. In addition, further study evaluating treatment approaches for Hoffa’s fat pad syndrome is required. BioMed Central 2023-06-09 /pmc/articles/PMC10251569/ /pubmed/37296488 http://dx.doi.org/10.1186/s43019-023-00192-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review Article
Abelleyra Lastoria, Diego Agustín
Benny, Clerin Kulangara
Hing, Caroline Blanca
Predisposing factors for Hoffa’s fat pad syndrome: a systematic review
title Predisposing factors for Hoffa’s fat pad syndrome: a systematic review
title_full Predisposing factors for Hoffa’s fat pad syndrome: a systematic review
title_fullStr Predisposing factors for Hoffa’s fat pad syndrome: a systematic review
title_full_unstemmed Predisposing factors for Hoffa’s fat pad syndrome: a systematic review
title_short Predisposing factors for Hoffa’s fat pad syndrome: a systematic review
title_sort predisposing factors for hoffa’s fat pad syndrome: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251569/
https://www.ncbi.nlm.nih.gov/pubmed/37296488
http://dx.doi.org/10.1186/s43019-023-00192-4
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