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Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study

BACKGROUND: This study investigated the effect of sex and age at type 2 diabetes (T2D) diagnosis on the influence of T2D-related genes, parental history of T2D, and obesity on T2D development. METHODS: In this case–control study, 1012 T2D cases and 1008 healthy subjects were selected from the Diabet...

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Autores principales: Berumen, Jaime, Orozco, Lorena, Gallardo-Rincón, Héctor, Rivas, Fernando, Barrera, Elizabeth, Benuto, Rosa E., García-Ortiz, Humberto, Marin-Medina, Melissa, Juárez-Torres, Eligia, Alvarado-Silva, Anabel, Ramos-Martinez, Espiridión, MartÍnez-Juárez, Luis Alberto, Lomelín-Gascón, Julieta, Montoya, Alejandra, Ortega-Montiel, Janinne, Alvarez-Hernández, Diego-Abelardo, Larriva-Shad, Jorge, Tapia-Conyer, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251612/
https://www.ncbi.nlm.nih.gov/pubmed/37291636
http://dx.doi.org/10.1186/s13293-023-00521-y
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author Berumen, Jaime
Orozco, Lorena
Gallardo-Rincón, Héctor
Rivas, Fernando
Barrera, Elizabeth
Benuto, Rosa E.
García-Ortiz, Humberto
Marin-Medina, Melissa
Juárez-Torres, Eligia
Alvarado-Silva, Anabel
Ramos-Martinez, Espiridión
MartÍnez-Juárez, Luis Alberto
Lomelín-Gascón, Julieta
Montoya, Alejandra
Ortega-Montiel, Janinne
Alvarez-Hernández, Diego-Abelardo
Larriva-Shad, Jorge
Tapia-Conyer, Roberto
author_facet Berumen, Jaime
Orozco, Lorena
Gallardo-Rincón, Héctor
Rivas, Fernando
Barrera, Elizabeth
Benuto, Rosa E.
García-Ortiz, Humberto
Marin-Medina, Melissa
Juárez-Torres, Eligia
Alvarado-Silva, Anabel
Ramos-Martinez, Espiridión
MartÍnez-Juárez, Luis Alberto
Lomelín-Gascón, Julieta
Montoya, Alejandra
Ortega-Montiel, Janinne
Alvarez-Hernández, Diego-Abelardo
Larriva-Shad, Jorge
Tapia-Conyer, Roberto
author_sort Berumen, Jaime
collection PubMed
description BACKGROUND: This study investigated the effect of sex and age at type 2 diabetes (T2D) diagnosis on the influence of T2D-related genes, parental history of T2D, and obesity on T2D development. METHODS: In this case–control study, 1012 T2D cases and 1008 healthy subjects were selected from the Diabetes in Mexico Study database. Participants were stratified by sex and age at T2D diagnosis (early, ≤ 45 years; late, ≥ 46 years). Sixty-nine T2D-associated single nucleotide polymorphisms were explored and the percentage contribution (R(2)) of T2D-related genes, parental history of T2D, and obesity (body mass index [BMI] and waist–hip ratio [WHR]) on T2D development was calculated using univariate and multivariate logistic regression models. RESULTS: T2D-related genes influenced T2D development most in males who were diagnosed early (R(2) = 23.5%; females, R(2) = 13.5%; males and females diagnosed late, R(2) = 11.9% and R(2) = 7.3%, respectively). With an early diagnosis, insulin production-related genes were more influential in males (76.0% of R(2)) while peripheral insulin resistance-associated genes were more influential in females (52.3% of R(2)). With a late diagnosis, insulin production-related genes from chromosome region 11p15.5 notably influenced males while peripheral insulin resistance and genes associated with inflammation and other processes notably influenced females. Influence of parental history was higher among those diagnosed early (males, 19.9%; females, 17.5%) versus late (males, 6.4%; females, 5,3%). Unilateral maternal T2D history was more influential than paternal T2D history. BMI influenced T2D development for all, while WHR exclusively influenced males. CONCLUSIONS: The influence of T2D-related genes, maternal T2D history, and fat distribution on T2D development was greater in males than females. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13293-023-00521-y.
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spelling pubmed-102516122023-06-10 Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study Berumen, Jaime Orozco, Lorena Gallardo-Rincón, Héctor Rivas, Fernando Barrera, Elizabeth Benuto, Rosa E. García-Ortiz, Humberto Marin-Medina, Melissa Juárez-Torres, Eligia Alvarado-Silva, Anabel Ramos-Martinez, Espiridión MartÍnez-Juárez, Luis Alberto Lomelín-Gascón, Julieta Montoya, Alejandra Ortega-Montiel, Janinne Alvarez-Hernández, Diego-Abelardo Larriva-Shad, Jorge Tapia-Conyer, Roberto Biol Sex Differ Research BACKGROUND: This study investigated the effect of sex and age at type 2 diabetes (T2D) diagnosis on the influence of T2D-related genes, parental history of T2D, and obesity on T2D development. METHODS: In this case–control study, 1012 T2D cases and 1008 healthy subjects were selected from the Diabetes in Mexico Study database. Participants were stratified by sex and age at T2D diagnosis (early, ≤ 45 years; late, ≥ 46 years). Sixty-nine T2D-associated single nucleotide polymorphisms were explored and the percentage contribution (R(2)) of T2D-related genes, parental history of T2D, and obesity (body mass index [BMI] and waist–hip ratio [WHR]) on T2D development was calculated using univariate and multivariate logistic regression models. RESULTS: T2D-related genes influenced T2D development most in males who were diagnosed early (R(2) = 23.5%; females, R(2) = 13.5%; males and females diagnosed late, R(2) = 11.9% and R(2) = 7.3%, respectively). With an early diagnosis, insulin production-related genes were more influential in males (76.0% of R(2)) while peripheral insulin resistance-associated genes were more influential in females (52.3% of R(2)). With a late diagnosis, insulin production-related genes from chromosome region 11p15.5 notably influenced males while peripheral insulin resistance and genes associated with inflammation and other processes notably influenced females. Influence of parental history was higher among those diagnosed early (males, 19.9%; females, 17.5%) versus late (males, 6.4%; females, 5,3%). Unilateral maternal T2D history was more influential than paternal T2D history. BMI influenced T2D development for all, while WHR exclusively influenced males. CONCLUSIONS: The influence of T2D-related genes, maternal T2D history, and fat distribution on T2D development was greater in males than females. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13293-023-00521-y. BioMed Central 2023-06-08 /pmc/articles/PMC10251612/ /pubmed/37291636 http://dx.doi.org/10.1186/s13293-023-00521-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Berumen, Jaime
Orozco, Lorena
Gallardo-Rincón, Héctor
Rivas, Fernando
Barrera, Elizabeth
Benuto, Rosa E.
García-Ortiz, Humberto
Marin-Medina, Melissa
Juárez-Torres, Eligia
Alvarado-Silva, Anabel
Ramos-Martinez, Espiridión
MartÍnez-Juárez, Luis Alberto
Lomelín-Gascón, Julieta
Montoya, Alejandra
Ortega-Montiel, Janinne
Alvarez-Hernández, Diego-Abelardo
Larriva-Shad, Jorge
Tapia-Conyer, Roberto
Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study
title Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study
title_full Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study
title_fullStr Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study
title_full_unstemmed Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study
title_short Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study
title_sort sex differences in the influence of type 2 diabetes (t2d)-related genes, parental history of t2d, and obesity on t2d development: a case–control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251612/
https://www.ncbi.nlm.nih.gov/pubmed/37291636
http://dx.doi.org/10.1186/s13293-023-00521-y
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