PlmCas12e (CasX2) cleavage of CCR5: impact of guide RNA spacer length and PAM sequence on cleavage activity

Gene editing using CRISPR/Cas (clustered regularly interspaced palindromic repeats/CRISPR-associated) is under development as a therapeutic tool for the modification of genes in eukaryotic cells. While much effort has focused on CRISPR/Cas9 systems from Streptococcus pyogenes and Staphylococcus aure...

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Detalles Bibliográficos
Autores principales: Armstrong, David A., Hudson, Taylor R., Hodge, Christine A., Hampton, Thomas H., Howell, Alexandra L., Hayden, Matthew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251783/
https://www.ncbi.nlm.nih.gov/pubmed/37287312
http://dx.doi.org/10.1080/15476286.2023.2221510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251783/
https://www.ncbi.nlm.nih.gov/pubmed/37287312
http://dx.doi.org/10.1080/15476286.2023.2221510

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