How ITD Insertion Sites Orchestrate the Biology and Disease of FLT3-ITD-Mutated Acute Myeloid Leukemia

SIMPLE SUMMARY: FLT3 gene mutations are among the most common genetic aberrations detected in AML and occur with a frequency of approximately 30%, mainly as internal tandem duplications (FLT3-ITD). As a novel finding, it has been reported that the specific insertion sites (IS) of FLT3-ITD exhibit ma...

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Detalles Bibliográficos
Autores principales: Haage, Tobias R., Schraven, Burkhart, Mougiakakos, Dimitrios, Fischer, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251898/
https://www.ncbi.nlm.nih.gov/pubmed/37296951
http://dx.doi.org/10.3390/cancers15112991

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