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Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment
SIMPLE SUMMARY: Recent reports focusing on the extent of plastic pollution have shown that petroleum-based products can currently be found in most marine species, which is a consequence of the immense production and use of plastics. The severe contamination of plastic nano-/microparticles (NPs/MPs)...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252065/ https://www.ncbi.nlm.nih.gov/pubmed/37889690 http://dx.doi.org/10.3390/ani13111810 |
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author | Savuca, Alexandra Nicoara, Mircea Nicușor Ciobica, Alin Gorgan, Dragos Lucian Ureche, Dorel Balmus, Ioana Miruna |
author_facet | Savuca, Alexandra Nicoara, Mircea Nicușor Ciobica, Alin Gorgan, Dragos Lucian Ureche, Dorel Balmus, Ioana Miruna |
author_sort | Savuca, Alexandra |
collection | PubMed |
description | SIMPLE SUMMARY: Recent reports focusing on the extent of plastic pollution have shown that petroleum-based products can currently be found in most marine species, which is a consequence of the immense production and use of plastics. The severe contamination of plastic nano-/microparticles (NPs/MPs) mainly results in immediate negative outcomes, such as organic impairments and tissue damage, as well as long-termed negative effects, such as developmental retardation and defects, chronic inflammation, oxidative stress (OS), metabolic imbalance, mutagenesis, and teratogenesis. We aimed to correlate the possible toxic effects of plastic NPs/MPs in zebrafish models, by focusing on OS and developmental processes, and the size, shape, and doses of the NPs/MPs. We found that plastic NPs/MPs toxic effects could be observed during the entire developmental span of zebrafish in close correlation with OS-related changes. The decreased antioxidant enzymatic defense due to plastic NPs/MPs exposure and accumulation suggests important neurodevelopmental negative outcomes (cognitive abnormalities, neurodevelopmental retardation, and behavioral impairments) and neuronal effects, such as impaired digestive physiology. ABSTRACT: Recent reports focusing on the extent of plastic pollution have shown that many types of fibers and polymers can now be found in most marine species. The severe contamination of plastic nano-/microparticles (NPs/MPs) mainly results in immediate negative outcomes, such as organic impairments and tissue damage, as well as long-termed negative effects, such as developmental retardation and defects, chronic inflammation, oxidative stress (OS), metabolic imbalance, mutagenesis, and teratogenesis. Oxidative responses are currently considered the first line molecular signal to potential toxic stimuli exposure, as the oxidative balance in electron exchange and reactive oxygen species signaling provides efficient harmful stimuli processing. Abnormal signaling or dysregulated ROS metabolism—OS—could be an important source of cellular toxicity, the source of a vicious cycle of environmental and oxidative signaling-derived toxicity. As chemical environmental pollutants, plastic NPs/MPs can also be a cause of such toxicity. Thus, we aimed to correlate the possible toxic effects of plastic NPs/MPs in zebrafish models, by focusing on OS and developmental processes. We found that plastic NPs/MPs toxic effects could be observed during the entire developmental span of zebrafish in close correlation with OS-related changes. Excessive ROS production and decreased antioxidant enzymatic defense due to plastic NPs/MPs exposure and accumulation were frequently associated with acetylcholinesterase activity inhibition, suggesting important neurodevelopmental negative outcomes (cognitive abnormalities, neurodevelopmental retardation, behavioral impairments) and extraneuronal effects, such as impaired digestive physiology. |
format | Online Article Text |
id | pubmed-10252065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102520652023-06-10 Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment Savuca, Alexandra Nicoara, Mircea Nicușor Ciobica, Alin Gorgan, Dragos Lucian Ureche, Dorel Balmus, Ioana Miruna Animals (Basel) Review SIMPLE SUMMARY: Recent reports focusing on the extent of plastic pollution have shown that petroleum-based products can currently be found in most marine species, which is a consequence of the immense production and use of plastics. The severe contamination of plastic nano-/microparticles (NPs/MPs) mainly results in immediate negative outcomes, such as organic impairments and tissue damage, as well as long-termed negative effects, such as developmental retardation and defects, chronic inflammation, oxidative stress (OS), metabolic imbalance, mutagenesis, and teratogenesis. We aimed to correlate the possible toxic effects of plastic NPs/MPs in zebrafish models, by focusing on OS and developmental processes, and the size, shape, and doses of the NPs/MPs. We found that plastic NPs/MPs toxic effects could be observed during the entire developmental span of zebrafish in close correlation with OS-related changes. The decreased antioxidant enzymatic defense due to plastic NPs/MPs exposure and accumulation suggests important neurodevelopmental negative outcomes (cognitive abnormalities, neurodevelopmental retardation, and behavioral impairments) and neuronal effects, such as impaired digestive physiology. ABSTRACT: Recent reports focusing on the extent of plastic pollution have shown that many types of fibers and polymers can now be found in most marine species. The severe contamination of plastic nano-/microparticles (NPs/MPs) mainly results in immediate negative outcomes, such as organic impairments and tissue damage, as well as long-termed negative effects, such as developmental retardation and defects, chronic inflammation, oxidative stress (OS), metabolic imbalance, mutagenesis, and teratogenesis. Oxidative responses are currently considered the first line molecular signal to potential toxic stimuli exposure, as the oxidative balance in electron exchange and reactive oxygen species signaling provides efficient harmful stimuli processing. Abnormal signaling or dysregulated ROS metabolism—OS—could be an important source of cellular toxicity, the source of a vicious cycle of environmental and oxidative signaling-derived toxicity. As chemical environmental pollutants, plastic NPs/MPs can also be a cause of such toxicity. Thus, we aimed to correlate the possible toxic effects of plastic NPs/MPs in zebrafish models, by focusing on OS and developmental processes. We found that plastic NPs/MPs toxic effects could be observed during the entire developmental span of zebrafish in close correlation with OS-related changes. Excessive ROS production and decreased antioxidant enzymatic defense due to plastic NPs/MPs exposure and accumulation were frequently associated with acetylcholinesterase activity inhibition, suggesting important neurodevelopmental negative outcomes (cognitive abnormalities, neurodevelopmental retardation, behavioral impairments) and extraneuronal effects, such as impaired digestive physiology. MDPI 2023-05-30 /pmc/articles/PMC10252065/ /pubmed/37889690 http://dx.doi.org/10.3390/ani13111810 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Savuca, Alexandra Nicoara, Mircea Nicușor Ciobica, Alin Gorgan, Dragos Lucian Ureche, Dorel Balmus, Ioana Miruna Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment |
title | Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment |
title_full | Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment |
title_fullStr | Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment |
title_full_unstemmed | Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment |
title_short | Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment |
title_sort | current aspects on the plastic nano- and microparticles toxicity in zebrafish—focus on the correlation between oxidative stress responses and neurodevelopment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252065/ https://www.ncbi.nlm.nih.gov/pubmed/37889690 http://dx.doi.org/10.3390/ani13111810 |
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