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Multiple Bone Destruction Secondary to Mycobacterium kansasii Pulmonary Disease: A Case Report

Mycobacterium kansasii infections predominantly manifest in immunocompromised people and are primarily responsible for lung disease and systemic disseminated infection. Osteopathy is a rare consequence of M. kansasii infection. Here, we present imaging data from a 44-year-old immunocompetent Chinese...

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Autores principales: Dai, Lu, Wu, Yanyan, Zhou, Xi, Liu, Sen, Fan, Junping, Xie, Huaiya, Wang, Luo, Tian, Xinlun, Xu, Wenbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252193/
https://www.ncbi.nlm.nih.gov/pubmed/37296822
http://dx.doi.org/10.3390/diagnostics13111970
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author Dai, Lu
Wu, Yanyan
Zhou, Xi
Liu, Sen
Fan, Junping
Xie, Huaiya
Wang, Luo
Tian, Xinlun
Xu, Wenbing
author_facet Dai, Lu
Wu, Yanyan
Zhou, Xi
Liu, Sen
Fan, Junping
Xie, Huaiya
Wang, Luo
Tian, Xinlun
Xu, Wenbing
author_sort Dai, Lu
collection PubMed
description Mycobacterium kansasii infections predominantly manifest in immunocompromised people and are primarily responsible for lung disease and systemic disseminated infection. Osteopathy is a rare consequence of M. kansasii infection. Here, we present imaging data from a 44-year-old immunocompetent Chinese woman diagnosed with multiple bone destruction, particularly of the spine, secondary to M. kansasii pulmonary disease, which is easily misdiagnosed. The patient underwent an emergency operation after experiencing unexpected incomplete paraplegia during hospitalization, indicating an aggravation of bone destruction. Preoperative sputum testing and next-generation sequencing of DNA and RNA of intraoperative samples confirmed the diagnosis of M. kansasii infection. Treatment with anti-tuberculosis therapy and the subsequent patient response supported our diagnosis. Given the rarity of osteopathy secondary to M. kansasii infection in immunocompetent individuals, our case offers some insight into this diagnosis.
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spelling pubmed-102521932023-06-10 Multiple Bone Destruction Secondary to Mycobacterium kansasii Pulmonary Disease: A Case Report Dai, Lu Wu, Yanyan Zhou, Xi Liu, Sen Fan, Junping Xie, Huaiya Wang, Luo Tian, Xinlun Xu, Wenbing Diagnostics (Basel) Interesting Images Mycobacterium kansasii infections predominantly manifest in immunocompromised people and are primarily responsible for lung disease and systemic disseminated infection. Osteopathy is a rare consequence of M. kansasii infection. Here, we present imaging data from a 44-year-old immunocompetent Chinese woman diagnosed with multiple bone destruction, particularly of the spine, secondary to M. kansasii pulmonary disease, which is easily misdiagnosed. The patient underwent an emergency operation after experiencing unexpected incomplete paraplegia during hospitalization, indicating an aggravation of bone destruction. Preoperative sputum testing and next-generation sequencing of DNA and RNA of intraoperative samples confirmed the diagnosis of M. kansasii infection. Treatment with anti-tuberculosis therapy and the subsequent patient response supported our diagnosis. Given the rarity of osteopathy secondary to M. kansasii infection in immunocompetent individuals, our case offers some insight into this diagnosis. MDPI 2023-06-05 /pmc/articles/PMC10252193/ /pubmed/37296822 http://dx.doi.org/10.3390/diagnostics13111970 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Dai, Lu
Wu, Yanyan
Zhou, Xi
Liu, Sen
Fan, Junping
Xie, Huaiya
Wang, Luo
Tian, Xinlun
Xu, Wenbing
Multiple Bone Destruction Secondary to Mycobacterium kansasii Pulmonary Disease: A Case Report
title Multiple Bone Destruction Secondary to Mycobacterium kansasii Pulmonary Disease: A Case Report
title_full Multiple Bone Destruction Secondary to Mycobacterium kansasii Pulmonary Disease: A Case Report
title_fullStr Multiple Bone Destruction Secondary to Mycobacterium kansasii Pulmonary Disease: A Case Report
title_full_unstemmed Multiple Bone Destruction Secondary to Mycobacterium kansasii Pulmonary Disease: A Case Report
title_short Multiple Bone Destruction Secondary to Mycobacterium kansasii Pulmonary Disease: A Case Report
title_sort multiple bone destruction secondary to mycobacterium kansasii pulmonary disease: a case report
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252193/
https://www.ncbi.nlm.nih.gov/pubmed/37296822
http://dx.doi.org/10.3390/diagnostics13111970
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