The Role of Peroxisome Proliferator-Activated Receptors in Endometrial Cancer

Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In order to investigate the role of PPARs in endometrial cancer, we conducted a...

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Detalles Bibliográficos
Autores principales: Psilopatis, Iason, Vrettou, Kleio, Troungos, Constantinos, Theocharis, Stamatios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252196/
https://www.ncbi.nlm.nih.gov/pubmed/37298140
http://dx.doi.org/10.3390/ijms24119190
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author Psilopatis, Iason
Vrettou, Kleio
Troungos, Constantinos
Theocharis, Stamatios
author_facet Psilopatis, Iason
Vrettou, Kleio
Troungos, Constantinos
Theocharis, Stamatios
author_sort Psilopatis, Iason
collection PubMed
description Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In order to investigate the role of PPARs in endometrial cancer, we conducted a literature review using the MEDLINE and LIVIVO databases and were able to identify 27 relevant studies published between 2000 and 2023. The PPARα and PPARβ/δ isoforms seemed to be upregulated, whereas PPARγ levels were reported to be significantly lower in endometrial cancer cells. Interestingly, PPAR agonists were found to represent potent anti-cancer therapeutic alternatives. In conclusion, PPARs seem to play a significant role in endometrial cancer.
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spelling pubmed-102521962023-06-10 The Role of Peroxisome Proliferator-Activated Receptors in Endometrial Cancer Psilopatis, Iason Vrettou, Kleio Troungos, Constantinos Theocharis, Stamatios Int J Mol Sci Review Endometrial carcinoma is the most common malignant tumor of the female genital tract in the United States. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins which regulate gene expression. In order to investigate the role of PPARs in endometrial cancer, we conducted a literature review using the MEDLINE and LIVIVO databases and were able to identify 27 relevant studies published between 2000 and 2023. The PPARα and PPARβ/δ isoforms seemed to be upregulated, whereas PPARγ levels were reported to be significantly lower in endometrial cancer cells. Interestingly, PPAR agonists were found to represent potent anti-cancer therapeutic alternatives. In conclusion, PPARs seem to play a significant role in endometrial cancer. MDPI 2023-05-24 /pmc/articles/PMC10252196/ /pubmed/37298140 http://dx.doi.org/10.3390/ijms24119190 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Psilopatis, Iason
Vrettou, Kleio
Troungos, Constantinos
Theocharis, Stamatios
The Role of Peroxisome Proliferator-Activated Receptors in Endometrial Cancer
title The Role of Peroxisome Proliferator-Activated Receptors in Endometrial Cancer
title_full The Role of Peroxisome Proliferator-Activated Receptors in Endometrial Cancer
title_fullStr The Role of Peroxisome Proliferator-Activated Receptors in Endometrial Cancer
title_full_unstemmed The Role of Peroxisome Proliferator-Activated Receptors in Endometrial Cancer
title_short The Role of Peroxisome Proliferator-Activated Receptors in Endometrial Cancer
title_sort role of peroxisome proliferator-activated receptors in endometrial cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252196/
https://www.ncbi.nlm.nih.gov/pubmed/37298140
http://dx.doi.org/10.3390/ijms24119190
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