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Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory?
We present the case of a 54-year-old male, without any significant medical history, who insidiously developed speech disturbances and walking difficulties, accompanied by backward falls. The symptoms progressively worsened over time. The patient was initially diagnosed with Parkinson’s disease; howe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252358/ https://www.ncbi.nlm.nih.gov/pubmed/37296819 http://dx.doi.org/10.3390/diagnostics13111967 |
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author | Lupascu, Nicoleta Lupescu, Ioan Cristian Caloianu, Ionuț Naftanaila, Florin Glogojeanu, Remus Relu Sirbu, Carmen Adella Mitrica, Marian |
author_facet | Lupascu, Nicoleta Lupescu, Ioan Cristian Caloianu, Ionuț Naftanaila, Florin Glogojeanu, Remus Relu Sirbu, Carmen Adella Mitrica, Marian |
author_sort | Lupascu, Nicoleta |
collection | PubMed |
description | We present the case of a 54-year-old male, without any significant medical history, who insidiously developed speech disturbances and walking difficulties, accompanied by backward falls. The symptoms progressively worsened over time. The patient was initially diagnosed with Parkinson’s disease; however, he failed to respond to standard therapy with Levodopa. He came to our attention for worsening postural instability and binocular diplopia. A neurological exam was highly suggestive of a Parkinson-plus disease, most likely progressive supranuclear gaze palsy. Brain MRI was performed and revealed moderate midbrain atrophy with the characteristic “hummingbird” and “Mickey mouse” signs. An increased MR parkinsonism index was also noted. Based on all clinical and paraclinical data, a diagnosis of probable progressive supranuclear palsy was established. We review the main imaging features of this disease and their current role in diagnosis. |
format | Online Article Text |
id | pubmed-10252358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102523582023-06-10 Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory? Lupascu, Nicoleta Lupescu, Ioan Cristian Caloianu, Ionuț Naftanaila, Florin Glogojeanu, Remus Relu Sirbu, Carmen Adella Mitrica, Marian Diagnostics (Basel) Interesting Images We present the case of a 54-year-old male, without any significant medical history, who insidiously developed speech disturbances and walking difficulties, accompanied by backward falls. The symptoms progressively worsened over time. The patient was initially diagnosed with Parkinson’s disease; however, he failed to respond to standard therapy with Levodopa. He came to our attention for worsening postural instability and binocular diplopia. A neurological exam was highly suggestive of a Parkinson-plus disease, most likely progressive supranuclear gaze palsy. Brain MRI was performed and revealed moderate midbrain atrophy with the characteristic “hummingbird” and “Mickey mouse” signs. An increased MR parkinsonism index was also noted. Based on all clinical and paraclinical data, a diagnosis of probable progressive supranuclear palsy was established. We review the main imaging features of this disease and their current role in diagnosis. MDPI 2023-06-05 /pmc/articles/PMC10252358/ /pubmed/37296819 http://dx.doi.org/10.3390/diagnostics13111967 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Interesting Images Lupascu, Nicoleta Lupescu, Ioan Cristian Caloianu, Ionuț Naftanaila, Florin Glogojeanu, Remus Relu Sirbu, Carmen Adella Mitrica, Marian Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory? |
title | Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory? |
title_full | Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory? |
title_fullStr | Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory? |
title_full_unstemmed | Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory? |
title_short | Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory? |
title_sort | imaging criteria for the diagnosis of progressive supranuclear palsy: supportive or mandatory? |
topic | Interesting Images |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252358/ https://www.ncbi.nlm.nih.gov/pubmed/37296819 http://dx.doi.org/10.3390/diagnostics13111967 |
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