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Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory?

We present the case of a 54-year-old male, without any significant medical history, who insidiously developed speech disturbances and walking difficulties, accompanied by backward falls. The symptoms progressively worsened over time. The patient was initially diagnosed with Parkinson’s disease; howe...

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Autores principales: Lupascu, Nicoleta, Lupescu, Ioan Cristian, Caloianu, Ionuț, Naftanaila, Florin, Glogojeanu, Remus Relu, Sirbu, Carmen Adella, Mitrica, Marian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252358/
https://www.ncbi.nlm.nih.gov/pubmed/37296819
http://dx.doi.org/10.3390/diagnostics13111967
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author Lupascu, Nicoleta
Lupescu, Ioan Cristian
Caloianu, Ionuț
Naftanaila, Florin
Glogojeanu, Remus Relu
Sirbu, Carmen Adella
Mitrica, Marian
author_facet Lupascu, Nicoleta
Lupescu, Ioan Cristian
Caloianu, Ionuț
Naftanaila, Florin
Glogojeanu, Remus Relu
Sirbu, Carmen Adella
Mitrica, Marian
author_sort Lupascu, Nicoleta
collection PubMed
description We present the case of a 54-year-old male, without any significant medical history, who insidiously developed speech disturbances and walking difficulties, accompanied by backward falls. The symptoms progressively worsened over time. The patient was initially diagnosed with Parkinson’s disease; however, he failed to respond to standard therapy with Levodopa. He came to our attention for worsening postural instability and binocular diplopia. A neurological exam was highly suggestive of a Parkinson-plus disease, most likely progressive supranuclear gaze palsy. Brain MRI was performed and revealed moderate midbrain atrophy with the characteristic “hummingbird” and “Mickey mouse” signs. An increased MR parkinsonism index was also noted. Based on all clinical and paraclinical data, a diagnosis of probable progressive supranuclear palsy was established. We review the main imaging features of this disease and their current role in diagnosis.
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spelling pubmed-102523582023-06-10 Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory? Lupascu, Nicoleta Lupescu, Ioan Cristian Caloianu, Ionuț Naftanaila, Florin Glogojeanu, Remus Relu Sirbu, Carmen Adella Mitrica, Marian Diagnostics (Basel) Interesting Images We present the case of a 54-year-old male, without any significant medical history, who insidiously developed speech disturbances and walking difficulties, accompanied by backward falls. The symptoms progressively worsened over time. The patient was initially diagnosed with Parkinson’s disease; however, he failed to respond to standard therapy with Levodopa. He came to our attention for worsening postural instability and binocular diplopia. A neurological exam was highly suggestive of a Parkinson-plus disease, most likely progressive supranuclear gaze palsy. Brain MRI was performed and revealed moderate midbrain atrophy with the characteristic “hummingbird” and “Mickey mouse” signs. An increased MR parkinsonism index was also noted. Based on all clinical and paraclinical data, a diagnosis of probable progressive supranuclear palsy was established. We review the main imaging features of this disease and their current role in diagnosis. MDPI 2023-06-05 /pmc/articles/PMC10252358/ /pubmed/37296819 http://dx.doi.org/10.3390/diagnostics13111967 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Lupascu, Nicoleta
Lupescu, Ioan Cristian
Caloianu, Ionuț
Naftanaila, Florin
Glogojeanu, Remus Relu
Sirbu, Carmen Adella
Mitrica, Marian
Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory?
title Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory?
title_full Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory?
title_fullStr Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory?
title_full_unstemmed Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory?
title_short Imaging Criteria for the Diagnosis of Progressive Supranuclear Palsy: Supportive or Mandatory?
title_sort imaging criteria for the diagnosis of progressive supranuclear palsy: supportive or mandatory?
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252358/
https://www.ncbi.nlm.nih.gov/pubmed/37296819
http://dx.doi.org/10.3390/diagnostics13111967
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