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Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease

Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and intolerance to cyclooxygenase-1 inhibitors. Interest is emerging in studying the role of circulating inflammatory cells in CRSwNP pathogenesis and its course,...

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Autores principales: Brescia, Giuseppe, Fabbris, Cristoforo, Calvanese, Leonardo, Bandolin, Luigia, Pedruzzi, Barbara, Di Pasquale Fiasca, Valerio Maria, Marciani, Silvia, Mularoni, Francesca, Degli Esposti Pallotti, Fabio, Negrisolo, Michael, Spinato, Giacomo, Frigo, Anna Chiara, Marioni, Gino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252406/
https://www.ncbi.nlm.nih.gov/pubmed/37296772
http://dx.doi.org/10.3390/diagnostics13111920
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author Brescia, Giuseppe
Fabbris, Cristoforo
Calvanese, Leonardo
Bandolin, Luigia
Pedruzzi, Barbara
Di Pasquale Fiasca, Valerio Maria
Marciani, Silvia
Mularoni, Francesca
Degli Esposti Pallotti, Fabio
Negrisolo, Michael
Spinato, Giacomo
Frigo, Anna Chiara
Marioni, Gino
author_facet Brescia, Giuseppe
Fabbris, Cristoforo
Calvanese, Leonardo
Bandolin, Luigia
Pedruzzi, Barbara
Di Pasquale Fiasca, Valerio Maria
Marciani, Silvia
Mularoni, Francesca
Degli Esposti Pallotti, Fabio
Negrisolo, Michael
Spinato, Giacomo
Frigo, Anna Chiara
Marioni, Gino
author_sort Brescia, Giuseppe
collection PubMed
description Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and intolerance to cyclooxygenase-1 inhibitors. Interest is emerging in studying the role of circulating inflammatory cells in CRSwNP pathogenesis and its course, as well as their potential use for a patient-tailored approach. By releasing IL-4, basophils play a crucial role in activating the Th2-mediated response. The main aim of this study was to, first, investigate the level of the pre-operative blood basophils’ values, blood basophil/lymphocyte ratio (bBLR) and blood eosinophil-to-basophil ratio (bEBR) as predictors of recurrent polyps after endoscopic sinus surgery (ESS) in AERD patients. The secondary aim was to compare the blood basophil-related variables of the AERD series (study group) with those of a control group of 95 consecutive cases of histologically non-eosinophilic CRSwNP. The AERD group showed a higher recurrence rate than the control group (p < 0.0001). The pre-operative blood basophil count and pre-operative bEBR were higher in AERD patients than in the control group (p = 0.0364 and p = 0.0006, respectively). The results of this study support the hypothesis that polyps removal may contribute to reducing the inflammation and activation of basophils.
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spelling pubmed-102524062023-06-10 Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease Brescia, Giuseppe Fabbris, Cristoforo Calvanese, Leonardo Bandolin, Luigia Pedruzzi, Barbara Di Pasquale Fiasca, Valerio Maria Marciani, Silvia Mularoni, Francesca Degli Esposti Pallotti, Fabio Negrisolo, Michael Spinato, Giacomo Frigo, Anna Chiara Marioni, Gino Diagnostics (Basel) Article Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and intolerance to cyclooxygenase-1 inhibitors. Interest is emerging in studying the role of circulating inflammatory cells in CRSwNP pathogenesis and its course, as well as their potential use for a patient-tailored approach. By releasing IL-4, basophils play a crucial role in activating the Th2-mediated response. The main aim of this study was to, first, investigate the level of the pre-operative blood basophils’ values, blood basophil/lymphocyte ratio (bBLR) and blood eosinophil-to-basophil ratio (bEBR) as predictors of recurrent polyps after endoscopic sinus surgery (ESS) in AERD patients. The secondary aim was to compare the blood basophil-related variables of the AERD series (study group) with those of a control group of 95 consecutive cases of histologically non-eosinophilic CRSwNP. The AERD group showed a higher recurrence rate than the control group (p < 0.0001). The pre-operative blood basophil count and pre-operative bEBR were higher in AERD patients than in the control group (p = 0.0364 and p = 0.0006, respectively). The results of this study support the hypothesis that polyps removal may contribute to reducing the inflammation and activation of basophils. MDPI 2023-05-31 /pmc/articles/PMC10252406/ /pubmed/37296772 http://dx.doi.org/10.3390/diagnostics13111920 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Brescia, Giuseppe
Fabbris, Cristoforo
Calvanese, Leonardo
Bandolin, Luigia
Pedruzzi, Barbara
Di Pasquale Fiasca, Valerio Maria
Marciani, Silvia
Mularoni, Francesca
Degli Esposti Pallotti, Fabio
Negrisolo, Michael
Spinato, Giacomo
Frigo, Anna Chiara
Marioni, Gino
Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease
title Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease
title_full Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease
title_fullStr Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease
title_full_unstemmed Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease
title_short Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease
title_sort blood basophils relevance in chronic rhinosinusitis with aspirin-exacerbated respiratory disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252406/
https://www.ncbi.nlm.nih.gov/pubmed/37296772
http://dx.doi.org/10.3390/diagnostics13111920
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