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Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion
Loss of the β cell population is a crucial feature of type 2 diabetes. Restoring the β cell mass by stimulating β cell proliferation and preventing its apoptosis was proposed as a therapeutic approach to treating diabetes. Therefore, researchers have been increasingly interested in identifying exoge...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252465/ https://www.ncbi.nlm.nih.gov/pubmed/37298086 http://dx.doi.org/10.3390/ijms24119136 |
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author | Li, Min Zhang, Ruifan Ge, Qian Yue, Lingzhi Ma, Dan Khattab, Firas Xie, Wenhua Cui, Yewei Gilon, Patrick Zhao, Xueya Li, Xi Cheng, Rui |
author_facet | Li, Min Zhang, Ruifan Ge, Qian Yue, Lingzhi Ma, Dan Khattab, Firas Xie, Wenhua Cui, Yewei Gilon, Patrick Zhao, Xueya Li, Xi Cheng, Rui |
author_sort | Li, Min |
collection | PubMed |
description | Loss of the β cell population is a crucial feature of type 2 diabetes. Restoring the β cell mass by stimulating β cell proliferation and preventing its apoptosis was proposed as a therapeutic approach to treating diabetes. Therefore, researchers have been increasingly interested in identifying exogenous factors that can stimulate β cell proliferation in situ and in vitro. Adipokine chemerin, which is secreted from adipose tissue and the liver, has been identified as a chemokine that plays a critical role in the regulation of metabolism. In this study, we demonstrate that chemerin as a circulating adipokine promotes β cell proliferation in vivo and in vitro. Chemerin serum levels and the expression of the main receptors within islets are highly regulated under a variety of challenging conditions, including obesity and type 2 diabetes. As compared to their littermates, mice overexpressing chemerin had a larger islet area and increased β cell mass with both a normal and high-fat diet. Moreover, in chemerin-overexpressed mice, we observed improved mitochondrial homeostasis and increased insulin synthesis. In summary, our findings confirm the potential role of chemerin as an inducer of β cell proliferation, and they provide novel insights into the helpful strategy to expand β cell population. |
format | Online Article Text |
id | pubmed-10252465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102524652023-06-10 Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion Li, Min Zhang, Ruifan Ge, Qian Yue, Lingzhi Ma, Dan Khattab, Firas Xie, Wenhua Cui, Yewei Gilon, Patrick Zhao, Xueya Li, Xi Cheng, Rui Int J Mol Sci Article Loss of the β cell population is a crucial feature of type 2 diabetes. Restoring the β cell mass by stimulating β cell proliferation and preventing its apoptosis was proposed as a therapeutic approach to treating diabetes. Therefore, researchers have been increasingly interested in identifying exogenous factors that can stimulate β cell proliferation in situ and in vitro. Adipokine chemerin, which is secreted from adipose tissue and the liver, has been identified as a chemokine that plays a critical role in the regulation of metabolism. In this study, we demonstrate that chemerin as a circulating adipokine promotes β cell proliferation in vivo and in vitro. Chemerin serum levels and the expression of the main receptors within islets are highly regulated under a variety of challenging conditions, including obesity and type 2 diabetes. As compared to their littermates, mice overexpressing chemerin had a larger islet area and increased β cell mass with both a normal and high-fat diet. Moreover, in chemerin-overexpressed mice, we observed improved mitochondrial homeostasis and increased insulin synthesis. In summary, our findings confirm the potential role of chemerin as an inducer of β cell proliferation, and they provide novel insights into the helpful strategy to expand β cell population. MDPI 2023-05-23 /pmc/articles/PMC10252465/ /pubmed/37298086 http://dx.doi.org/10.3390/ijms24119136 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Min Zhang, Ruifan Ge, Qian Yue, Lingzhi Ma, Dan Khattab, Firas Xie, Wenhua Cui, Yewei Gilon, Patrick Zhao, Xueya Li, Xi Cheng, Rui Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion |
title | Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion |
title_full | Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion |
title_fullStr | Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion |
title_full_unstemmed | Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion |
title_short | Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion |
title_sort | chemerin as an inducer of β cell proliferation mediates mitochondrial homeostasis and promotes β cell mass expansion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252465/ https://www.ncbi.nlm.nih.gov/pubmed/37298086 http://dx.doi.org/10.3390/ijms24119136 |
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