Low CDK Activity and Enhanced Degradation by APC/C(CDH1) Abolishes CtIP Activity and Alt-EJ in Quiescent Cells

Alt-EJ is an error-prone DNA double-strand break (DSBs) repair pathway coming to the fore when first-line repair pathways, c-NHEJ and HR, are defective or fail. It is thought to benefit from DNA end-resection—a process whereby 3′ single-stranded DNA-tails are generated—initiated by the CtIP/MRE11-RA...

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Detalles Bibliográficos
Autores principales: Li, Fanghua, Mladenov, Emil, Sun, Yanjie, Soni, Aashish, Stuschke, Martin, Timmermann, Beate, Iliakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252496/
https://www.ncbi.nlm.nih.gov/pubmed/37296650
http://dx.doi.org/10.3390/cells12111530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252496/
https://www.ncbi.nlm.nih.gov/pubmed/37296650
http://dx.doi.org/10.3390/cells12111530

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