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The Role of IL-18 in P2RX7-Mediated Antitumor Immunity
Cancer is the leading cause of death worldwide despite the variety of treatments that are currently used. This is due to an innate or acquired resistance to therapy that encourages the discovery of novel therapeutic strategies to overcome the resistance. This review will focus on the role of the pur...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252498/ https://www.ncbi.nlm.nih.gov/pubmed/37298187 http://dx.doi.org/10.3390/ijms24119235 |
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author | Janho dit Hreich, Serena Hofman, Paul Vouret-Craviari, Valérie |
author_facet | Janho dit Hreich, Serena Hofman, Paul Vouret-Craviari, Valérie |
author_sort | Janho dit Hreich, Serena |
collection | PubMed |
description | Cancer is the leading cause of death worldwide despite the variety of treatments that are currently used. This is due to an innate or acquired resistance to therapy that encourages the discovery of novel therapeutic strategies to overcome the resistance. This review will focus on the role of the purinergic receptor P2RX7 in the control of tumor growth, through its ability to modulate antitumor immunity by releasing IL-18. In particular, we describe how the ATP-induced receptor activities (cationic exchange, large pore opening and NLRP3 inflammasome activation) modulate immune cell functions. Furthermore, we recapitulate our current knowledge of the production of IL-18 downstream of P2RX7 activation and how IL-18 controls the fate of tumor growth. Finally, the potential of targeting the P2RX7/IL-18 pathway in combination with classical immunotherapies to fight cancer is discussed. |
format | Online Article Text |
id | pubmed-10252498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102524982023-06-10 The Role of IL-18 in P2RX7-Mediated Antitumor Immunity Janho dit Hreich, Serena Hofman, Paul Vouret-Craviari, Valérie Int J Mol Sci Review Cancer is the leading cause of death worldwide despite the variety of treatments that are currently used. This is due to an innate or acquired resistance to therapy that encourages the discovery of novel therapeutic strategies to overcome the resistance. This review will focus on the role of the purinergic receptor P2RX7 in the control of tumor growth, through its ability to modulate antitumor immunity by releasing IL-18. In particular, we describe how the ATP-induced receptor activities (cationic exchange, large pore opening and NLRP3 inflammasome activation) modulate immune cell functions. Furthermore, we recapitulate our current knowledge of the production of IL-18 downstream of P2RX7 activation and how IL-18 controls the fate of tumor growth. Finally, the potential of targeting the P2RX7/IL-18 pathway in combination with classical immunotherapies to fight cancer is discussed. MDPI 2023-05-25 /pmc/articles/PMC10252498/ /pubmed/37298187 http://dx.doi.org/10.3390/ijms24119235 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Janho dit Hreich, Serena Hofman, Paul Vouret-Craviari, Valérie The Role of IL-18 in P2RX7-Mediated Antitumor Immunity |
title | The Role of IL-18 in P2RX7-Mediated Antitumor Immunity |
title_full | The Role of IL-18 in P2RX7-Mediated Antitumor Immunity |
title_fullStr | The Role of IL-18 in P2RX7-Mediated Antitumor Immunity |
title_full_unstemmed | The Role of IL-18 in P2RX7-Mediated Antitumor Immunity |
title_short | The Role of IL-18 in P2RX7-Mediated Antitumor Immunity |
title_sort | role of il-18 in p2rx7-mediated antitumor immunity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252498/ https://www.ncbi.nlm.nih.gov/pubmed/37298187 http://dx.doi.org/10.3390/ijms24119235 |
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