Cargando…
Altered Metabolism in Motor Neuron Diseases: Mechanism and Potential Therapeutic Target
Motor Neuron Diseases (MND) are neurological disorders characterized by a loss of varying motor neurons resulting in decreased physical capabilities. Current research is focused on hindering disease progression by determining causes of motor neuron death. Metabolic malfunction has been proposed as a...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252517/ https://www.ncbi.nlm.nih.gov/pubmed/37296656 http://dx.doi.org/10.3390/cells12111536 |
_version_ | 1785056189955964928 |
---|---|
author | Barone, Cassandra Qi, Xin |
author_facet | Barone, Cassandra Qi, Xin |
author_sort | Barone, Cassandra |
collection | PubMed |
description | Motor Neuron Diseases (MND) are neurological disorders characterized by a loss of varying motor neurons resulting in decreased physical capabilities. Current research is focused on hindering disease progression by determining causes of motor neuron death. Metabolic malfunction has been proposed as a promising topic when targeting motor neuron loss. Alterations in metabolism have also been noted at the neuromuscular junction (NMJ) and skeletal muscle tissue, emphasizing the importance of a cohesive system. Finding metabolism changes consistent throughout both neurons and skeletal muscle tissue could pose as a target for therapeutic intervention. This review will focus on metabolic deficits reported in MNDs and propose potential therapeutic targets for future intervention. |
format | Online Article Text |
id | pubmed-10252517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102525172023-06-10 Altered Metabolism in Motor Neuron Diseases: Mechanism and Potential Therapeutic Target Barone, Cassandra Qi, Xin Cells Review Motor Neuron Diseases (MND) are neurological disorders characterized by a loss of varying motor neurons resulting in decreased physical capabilities. Current research is focused on hindering disease progression by determining causes of motor neuron death. Metabolic malfunction has been proposed as a promising topic when targeting motor neuron loss. Alterations in metabolism have also been noted at the neuromuscular junction (NMJ) and skeletal muscle tissue, emphasizing the importance of a cohesive system. Finding metabolism changes consistent throughout both neurons and skeletal muscle tissue could pose as a target for therapeutic intervention. This review will focus on metabolic deficits reported in MNDs and propose potential therapeutic targets for future intervention. MDPI 2023-06-02 /pmc/articles/PMC10252517/ /pubmed/37296656 http://dx.doi.org/10.3390/cells12111536 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Barone, Cassandra Qi, Xin Altered Metabolism in Motor Neuron Diseases: Mechanism and Potential Therapeutic Target |
title | Altered Metabolism in Motor Neuron Diseases: Mechanism and Potential Therapeutic Target |
title_full | Altered Metabolism in Motor Neuron Diseases: Mechanism and Potential Therapeutic Target |
title_fullStr | Altered Metabolism in Motor Neuron Diseases: Mechanism and Potential Therapeutic Target |
title_full_unstemmed | Altered Metabolism in Motor Neuron Diseases: Mechanism and Potential Therapeutic Target |
title_short | Altered Metabolism in Motor Neuron Diseases: Mechanism and Potential Therapeutic Target |
title_sort | altered metabolism in motor neuron diseases: mechanism and potential therapeutic target |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252517/ https://www.ncbi.nlm.nih.gov/pubmed/37296656 http://dx.doi.org/10.3390/cells12111536 |
work_keys_str_mv | AT baronecassandra alteredmetabolisminmotorneurondiseasesmechanismandpotentialtherapeutictarget AT qixin alteredmetabolisminmotorneurondiseasesmechanismandpotentialtherapeutictarget |