Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain

Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the discovery of their relation to pain processing control, they are investigated to find new strategies for better pain control. This review provides an overview of naturally based and synthetic VGCC blockers, highl...

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Detalles Bibliográficos
Autores principales: Antunes, Flavia Tasmin Techera, Campos, Maria Martha, Carvalho, Vanice de Paula Ricardo, da Silva Junior, Claudio Antonio, Magno, Luiz Alexandre Viana, de Souza, Alessandra Hubner, Gomez, Marcus Vinicius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252546/
https://www.ncbi.nlm.nih.gov/pubmed/37298174
http://dx.doi.org/10.3390/ijms24119223
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author Antunes, Flavia Tasmin Techera
Campos, Maria Martha
Carvalho, Vanice de Paula Ricardo
da Silva Junior, Claudio Antonio
Magno, Luiz Alexandre Viana
de Souza, Alessandra Hubner
Gomez, Marcus Vinicius
author_facet Antunes, Flavia Tasmin Techera
Campos, Maria Martha
Carvalho, Vanice de Paula Ricardo
da Silva Junior, Claudio Antonio
Magno, Luiz Alexandre Viana
de Souza, Alessandra Hubner
Gomez, Marcus Vinicius
author_sort Antunes, Flavia Tasmin Techera
collection PubMed
description Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the discovery of their relation to pain processing control, they are investigated to find new strategies for better pain control. This review provides an overview of naturally based and synthetic VGCC blockers, highlighting new evidence on the development of drugs focusing on the VGCC subtypes as well as mixed targets with pre-clinical and clinical analgesic effects.
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spelling pubmed-102525462023-06-10 Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain Antunes, Flavia Tasmin Techera Campos, Maria Martha Carvalho, Vanice de Paula Ricardo da Silva Junior, Claudio Antonio Magno, Luiz Alexandre Viana de Souza, Alessandra Hubner Gomez, Marcus Vinicius Int J Mol Sci Review Voltage-gated calcium channels (VGCCs) are targeted to treat pain conditions. Since the discovery of their relation to pain processing control, they are investigated to find new strategies for better pain control. This review provides an overview of naturally based and synthetic VGCC blockers, highlighting new evidence on the development of drugs focusing on the VGCC subtypes as well as mixed targets with pre-clinical and clinical analgesic effects. MDPI 2023-05-25 /pmc/articles/PMC10252546/ /pubmed/37298174 http://dx.doi.org/10.3390/ijms24119223 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Antunes, Flavia Tasmin Techera
Campos, Maria Martha
Carvalho, Vanice de Paula Ricardo
da Silva Junior, Claudio Antonio
Magno, Luiz Alexandre Viana
de Souza, Alessandra Hubner
Gomez, Marcus Vinicius
Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain
title Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain
title_full Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain
title_fullStr Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain
title_full_unstemmed Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain
title_short Current Drug Development Overview: Targeting Voltage-Gated Calcium Channels for the Treatment of Pain
title_sort current drug development overview: targeting voltage-gated calcium channels for the treatment of pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252546/
https://www.ncbi.nlm.nih.gov/pubmed/37298174
http://dx.doi.org/10.3390/ijms24119223
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