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Prediction of Diabetic Macular Edema Using Knowledge Graph

Diabetic macular edema (DME) is a significant complication of diabetes that impacts the eye and is a primary contributor to vision loss in individuals with diabetes. Early control of the related risk factors is crucial to reduce the incidence of DME. Artificial intelligence (AI) clinical decision-ma...

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Autores principales: Li, Zhi-Qing, Fu, Zi-Xuan, Li, Wen-Jun, Fan, Hao, Li, Shu-Nan, Wang, Xi-Mo, Zhou, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252678/
https://www.ncbi.nlm.nih.gov/pubmed/37296709
http://dx.doi.org/10.3390/diagnostics13111858
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author Li, Zhi-Qing
Fu, Zi-Xuan
Li, Wen-Jun
Fan, Hao
Li, Shu-Nan
Wang, Xi-Mo
Zhou, Peng
author_facet Li, Zhi-Qing
Fu, Zi-Xuan
Li, Wen-Jun
Fan, Hao
Li, Shu-Nan
Wang, Xi-Mo
Zhou, Peng
author_sort Li, Zhi-Qing
collection PubMed
description Diabetic macular edema (DME) is a significant complication of diabetes that impacts the eye and is a primary contributor to vision loss in individuals with diabetes. Early control of the related risk factors is crucial to reduce the incidence of DME. Artificial intelligence (AI) clinical decision-making tools can construct disease prediction models to aid in the clinical screening of the high-risk population for early disease intervention. However, conventional machine learning and data mining techniques have limitations in predicting diseases when dealing with missing feature values. To solve this problem, a knowledge graph displays the connection relationships of multi-source and multi-domain data in the form of a semantic network to enable cross-domain modeling and queries. This approach can facilitate the personalized prediction of diseases using any number of known feature data. In this study, we proposed an improved correlation enhancement algorithm based on knowledge graph reasoning to comprehensively evaluate the factors that influence DME to achieve disease prediction. We constructed a knowledge graph based on Neo4j by preprocessing the collected clinical data and analyzing the statistical rules. Based on reasoning using the statistical rules of the knowledge graph, we used the correlation enhancement coefficient and generalized closeness degree method to enhance the model. Meanwhile, we analyzed and verified these models’ results using link prediction evaluation indicators. The disease prediction model proposed in this study achieved a precision rate of 86.21%, which is more accurate and efficient in predicting DME. Furthermore, the clinical decision support system developed using this model can facilitate personalized disease risk prediction, making it convenient for the clinical screening of a high-risk population and early disease intervention.
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spelling pubmed-102526782023-06-10 Prediction of Diabetic Macular Edema Using Knowledge Graph Li, Zhi-Qing Fu, Zi-Xuan Li, Wen-Jun Fan, Hao Li, Shu-Nan Wang, Xi-Mo Zhou, Peng Diagnostics (Basel) Article Diabetic macular edema (DME) is a significant complication of diabetes that impacts the eye and is a primary contributor to vision loss in individuals with diabetes. Early control of the related risk factors is crucial to reduce the incidence of DME. Artificial intelligence (AI) clinical decision-making tools can construct disease prediction models to aid in the clinical screening of the high-risk population for early disease intervention. However, conventional machine learning and data mining techniques have limitations in predicting diseases when dealing with missing feature values. To solve this problem, a knowledge graph displays the connection relationships of multi-source and multi-domain data in the form of a semantic network to enable cross-domain modeling and queries. This approach can facilitate the personalized prediction of diseases using any number of known feature data. In this study, we proposed an improved correlation enhancement algorithm based on knowledge graph reasoning to comprehensively evaluate the factors that influence DME to achieve disease prediction. We constructed a knowledge graph based on Neo4j by preprocessing the collected clinical data and analyzing the statistical rules. Based on reasoning using the statistical rules of the knowledge graph, we used the correlation enhancement coefficient and generalized closeness degree method to enhance the model. Meanwhile, we analyzed and verified these models’ results using link prediction evaluation indicators. The disease prediction model proposed in this study achieved a precision rate of 86.21%, which is more accurate and efficient in predicting DME. Furthermore, the clinical decision support system developed using this model can facilitate personalized disease risk prediction, making it convenient for the clinical screening of a high-risk population and early disease intervention. MDPI 2023-05-26 /pmc/articles/PMC10252678/ /pubmed/37296709 http://dx.doi.org/10.3390/diagnostics13111858 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Zhi-Qing
Fu, Zi-Xuan
Li, Wen-Jun
Fan, Hao
Li, Shu-Nan
Wang, Xi-Mo
Zhou, Peng
Prediction of Diabetic Macular Edema Using Knowledge Graph
title Prediction of Diabetic Macular Edema Using Knowledge Graph
title_full Prediction of Diabetic Macular Edema Using Knowledge Graph
title_fullStr Prediction of Diabetic Macular Edema Using Knowledge Graph
title_full_unstemmed Prediction of Diabetic Macular Edema Using Knowledge Graph
title_short Prediction of Diabetic Macular Edema Using Knowledge Graph
title_sort prediction of diabetic macular edema using knowledge graph
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252678/
https://www.ncbi.nlm.nih.gov/pubmed/37296709
http://dx.doi.org/10.3390/diagnostics13111858
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