Cargando…

XPF–ERCC1 Blocker Improves the Therapeutic Efficacy of 5-FU- and Oxaliplatin-Based Chemoradiotherapy in Colorectal Cancer

5-FU-based chemoradiotherapy (CRT) and oxaliplatin-based CRT are commonly used therapies for advanced colorectal cancer (CRC). However, patients with a high expression of ERCC1 have a worse prognosis than those with a low expression. In this study, we investigated the effect of XPF–ERCC1 blockers on...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Ming-Yii, Huang, Yi-Jung, Cheng, Tian-Lu, Jhang, Wun-Ya, Ke, Chien-Chih, Chen, Yi-Ting, Kuo, Shih-Hsun, Lin, I-Ling, Huang, Yu-Hsiang, Chuang, Chih-Hung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252687/ https://www.ncbi.nlm.nih.gov/pubmed/37296596 http://dx.doi.org/10.3390/cells12111475

Ejemplares similares

HIF-1α Expression Increases Preoperative Concurrent Chemoradiotherapy Resistance in Hyperglycemic Rectal Cancer
por: Huang, Yi-Jung, et al.
Publicado: (2022)

ERCC1 Overexpression Increases Radioresistance in Colorectal Cancer Cells
por: Huang, Yi-Jung, et al.
Publicado: (2022)

Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation
por: Wang, Jiajia, et al.
Publicado: (2020)

Association of ERCC1 and XPF polymorphisms with pediatric glioma susceptibility
por: Chen, Yongping, et al.
Publicado: (2023)

Expression and Clinical Significance of ERCC1 and XPF in Human Hepatocellular Carcinoma
por: Liao, Xiaoli, et al.
Publicado: (2020)

XPF–ERCC1: Linchpin of DNA crosslink repair
por: McHugh, Peter J.
Publicado: (2020)

Function and Interactions of ERCC1-XPF in DNA Damage Response
por: Faridounnia, Maryam, et al.
Publicado: (2018)

Polymorphisms in ERCC1 and XPF Genes and Risk of Gastric Cancer in an Eastern Chinese Population
por: He, Jing, et al.
Publicado: (2012)

ERCC1/XPF Protects Short Telomeres from Homologous Recombination in Arabidopsis thaliana
por: Vannier, Jean-Baptiste, et al.
Publicado: (2009)

Functional Polymorphisms at ERCC1/XPF Genes Confer Neuroblastoma Risk in Chinese Children
por: Zhuo, Zhen-Jian, et al.
Publicado: (2018)

RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks
por: Abdullah, Ummi B, et al.
Publicado: (2017)

ERCC1–XPF targeting to psoralen–DNA crosslinks depends on XPA and FANCD2
por: Sabatella, Mariangela, et al.
Publicado: (2019)

Distribution and susceptibility of ERCC1/XPF gene polymorphisms in Han and Uygur women with breast cancer in Xinjiang, China
por: Li, Hongtao, et al.
Publicado: (2020)

Mislocalization of XPF-ERCC1 Nuclease Contributes to Reduced DNA Repair in XP-F Patients
por: Ahmad, Anwaar, et al.
Publicado: (2010)

USP45 deubiquitylase controls ERCC1–XPF endonuclease-mediated DNA damage responses
por: Perez-Oliva, Ana B, et al.
Publicado: (2015)

Recruitment and positioning determine the specific role of the XPF‐ERCC1 endonuclease in interstrand crosslink repair
por: Klein Douwel, Daisy, et al.
Publicado: (2017)

ERCC1/XPF Is Important for Repair of DNA Double-Strand Breaks Containing Secondary Structures
por: Li, Shibo, et al.
Publicado: (2019)

The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing
por: Goulielmaki, Evi, et al.
Publicado: (2021)

The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells
por: Al-Minawi, Ali Z., et al.
Publicado: (2008)

The XPF-ERCC1 Complex Is Essential for Genome Stability and Is Involved in the Mechanism of Gene Targeting in Physcomitrella patens
por: Guyon-Debast, Anouchka, et al.
Publicado: (2019)

SLX4IP acts with SLX4 and XPF–ERCC1 to promote interstrand crosslink repair
por: Zhang, Huimin, et al.
Publicado: (2019)

XPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathways
por: Mulderrig, Lee, et al.
Publicado: (2020)

Polymorphisms in ERCC5 rs17655 and ERCC1 rs735482 Genes Associated with the Survival of Male Patients with Postoperative Oral Squamous Cell Carcinoma Treated with Adjuvant Concurrent Chemoradiotherapy
por: Senghore, Thomas, et al.
Publicado: (2019)

Computational Characterization of Small Molecules Binding to the Human XPF Active Site and Virtual Screening to Identify Potential New DNA Repair Inhibitors Targeting the ERCC1-XPF Endonuclease
por: Gentile, Francesco, et al.
Publicado: (2018)

DNA repair endonuclease ERCC1–XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy
por: McNeil, Ewan M., et al.
Publicado: (2012)

Modulation of ERCC1-XPF Heterodimerization Inhibition via Structural Modification of Small Molecule Inhibitor Side-Chains
por: Weilbeer, Claudia, et al.
Publicado: (2022)

Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression
por: Usanova, Svetlana, et al.
Publicado: (2010)

Fluorescence-based incision assay for human XPF–ERCC1 activity identifies important elements of DNA junction recognition
por: Bowles, Maureen, et al.
Publicado: (2012)

Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair
por: Hodskinson, Michael R.G., et al.
Publicado: (2014)

A meiotic XPF–ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation
por: De Muyt, Arnaud, et al.
Publicado: (2018)

Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells
por: Arora, Sanjeevani, et al.
Publicado: (2016)

Impact of ERCC1, XPF and DNA Polymerase β Expression on Platinum Response in Patient-Derived Ovarian Cancer Xenografts
por: Guffanti, Federica, et al.
Publicado: (2020)

Five-year survival outcomes of intensity-modulated radiotherapy with simultaneous integrated boost (IMRT-SIB) using forward IMRT or Tomotherapy for breast cancer
por: Lee, Hsin-Hua, et al.
Publicado: (2020)

Combined Ki67 and ERCC1 for prognosis in non-keratinizing nasopharyngeal carcinoma underwent chemoradiotherapy
por: Lu, Ying, et al.
Publicado: (2017)

XPF activates break-induced telomere synthesis
por: Guh, Chia-Yu, et al.
Publicado: (2022)

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links
por: Al-Minawi, Ali Z., et al.
Publicado: (2009)

Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3′-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease
por: Yamamoto, Junpei, et al.
Publicado: (2016)

Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation
por: Jones, Morgan, et al.
Publicado: (2020)

Association between ERCC1 and TS mRNA levels and disease free survival in colorectal cancer patients receiving oxaliplatin and fluorouracil (5-FU) adjuvant chemotherapy
por: Li, Sheng, et al.
Publicado: (2014)

Biomarkers of Favorable vs. Unfavorable Responses in Locally Advanced Rectal Cancer Patients Receiving Neoadjuvant Concurrent Chemoradiotherapy
por: Lee, Hsin-Hua, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_e0jad89eebhic0s1op6d0eh1es