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Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration
Liver regeneration has been studied for many decades, and the mechanisms underlying regeneration of normal liver following resection are well described. However, no less relevant is the study of mechanisms that disrupt the process of liver regeneration. First of all, a violation of liver regeneratio...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252688/ https://www.ncbi.nlm.nih.gov/pubmed/37298064 http://dx.doi.org/10.3390/ijms24119112 |
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author | Rodimova, Svetlana Mozherov, Artem Elagin, Vadim Karabut, Maria Shchechkin, Ilya Kozlov, Dmitry Krylov, Dmitry Gavrina, Alena Bobrov, Nikolai Zagainov, Vladimir Zagaynova, Elena Kuznetsova, Daria |
author_facet | Rodimova, Svetlana Mozherov, Artem Elagin, Vadim Karabut, Maria Shchechkin, Ilya Kozlov, Dmitry Krylov, Dmitry Gavrina, Alena Bobrov, Nikolai Zagainov, Vladimir Zagaynova, Elena Kuznetsova, Daria |
author_sort | Rodimova, Svetlana |
collection | PubMed |
description | Liver regeneration has been studied for many decades, and the mechanisms underlying regeneration of normal liver following resection are well described. However, no less relevant is the study of mechanisms that disrupt the process of liver regeneration. First of all, a violation of liver regeneration can occur in the presence of concomitant hepatic pathology, which is a key factor reducing the liver’s regenerative potential. Understanding these mechanisms could enable the rational targeting of specific therapies to either reduce the factors inhibiting regeneration or to directly stimulate liver regeneration. This review describes the known mechanisms of normal liver regeneration and factors that reduce its regenerative potential, primarily at the level of hepatocyte metabolism, in the presence of concomitant hepatic pathology. We also briefly discuss promising strategies for stimulating liver regeneration and those concerning methods for assessing the regenerative potential of the liver, especially intraoperatively. |
format | Online Article Text |
id | pubmed-10252688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102526882023-06-10 Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration Rodimova, Svetlana Mozherov, Artem Elagin, Vadim Karabut, Maria Shchechkin, Ilya Kozlov, Dmitry Krylov, Dmitry Gavrina, Alena Bobrov, Nikolai Zagainov, Vladimir Zagaynova, Elena Kuznetsova, Daria Int J Mol Sci Review Liver regeneration has been studied for many decades, and the mechanisms underlying regeneration of normal liver following resection are well described. However, no less relevant is the study of mechanisms that disrupt the process of liver regeneration. First of all, a violation of liver regeneration can occur in the presence of concomitant hepatic pathology, which is a key factor reducing the liver’s regenerative potential. Understanding these mechanisms could enable the rational targeting of specific therapies to either reduce the factors inhibiting regeneration or to directly stimulate liver regeneration. This review describes the known mechanisms of normal liver regeneration and factors that reduce its regenerative potential, primarily at the level of hepatocyte metabolism, in the presence of concomitant hepatic pathology. We also briefly discuss promising strategies for stimulating liver regeneration and those concerning methods for assessing the regenerative potential of the liver, especially intraoperatively. MDPI 2023-05-23 /pmc/articles/PMC10252688/ /pubmed/37298064 http://dx.doi.org/10.3390/ijms24119112 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rodimova, Svetlana Mozherov, Artem Elagin, Vadim Karabut, Maria Shchechkin, Ilya Kozlov, Dmitry Krylov, Dmitry Gavrina, Alena Bobrov, Nikolai Zagainov, Vladimir Zagaynova, Elena Kuznetsova, Daria Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration |
title | Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration |
title_full | Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration |
title_fullStr | Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration |
title_full_unstemmed | Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration |
title_short | Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration |
title_sort | effect of hepatic pathology on liver regeneration: the main metabolic mechanisms causing impaired hepatic regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252688/ https://www.ncbi.nlm.nih.gov/pubmed/37298064 http://dx.doi.org/10.3390/ijms24119112 |
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