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Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration

Liver regeneration has been studied for many decades, and the mechanisms underlying regeneration of normal liver following resection are well described. However, no less relevant is the study of mechanisms that disrupt the process of liver regeneration. First of all, a violation of liver regeneratio...

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Autores principales: Rodimova, Svetlana, Mozherov, Artem, Elagin, Vadim, Karabut, Maria, Shchechkin, Ilya, Kozlov, Dmitry, Krylov, Dmitry, Gavrina, Alena, Bobrov, Nikolai, Zagainov, Vladimir, Zagaynova, Elena, Kuznetsova, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252688/
https://www.ncbi.nlm.nih.gov/pubmed/37298064
http://dx.doi.org/10.3390/ijms24119112
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author Rodimova, Svetlana
Mozherov, Artem
Elagin, Vadim
Karabut, Maria
Shchechkin, Ilya
Kozlov, Dmitry
Krylov, Dmitry
Gavrina, Alena
Bobrov, Nikolai
Zagainov, Vladimir
Zagaynova, Elena
Kuznetsova, Daria
author_facet Rodimova, Svetlana
Mozherov, Artem
Elagin, Vadim
Karabut, Maria
Shchechkin, Ilya
Kozlov, Dmitry
Krylov, Dmitry
Gavrina, Alena
Bobrov, Nikolai
Zagainov, Vladimir
Zagaynova, Elena
Kuznetsova, Daria
author_sort Rodimova, Svetlana
collection PubMed
description Liver regeneration has been studied for many decades, and the mechanisms underlying regeneration of normal liver following resection are well described. However, no less relevant is the study of mechanisms that disrupt the process of liver regeneration. First of all, a violation of liver regeneration can occur in the presence of concomitant hepatic pathology, which is a key factor reducing the liver’s regenerative potential. Understanding these mechanisms could enable the rational targeting of specific therapies to either reduce the factors inhibiting regeneration or to directly stimulate liver regeneration. This review describes the known mechanisms of normal liver regeneration and factors that reduce its regenerative potential, primarily at the level of hepatocyte metabolism, in the presence of concomitant hepatic pathology. We also briefly discuss promising strategies for stimulating liver regeneration and those concerning methods for assessing the regenerative potential of the liver, especially intraoperatively.
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spelling pubmed-102526882023-06-10 Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration Rodimova, Svetlana Mozherov, Artem Elagin, Vadim Karabut, Maria Shchechkin, Ilya Kozlov, Dmitry Krylov, Dmitry Gavrina, Alena Bobrov, Nikolai Zagainov, Vladimir Zagaynova, Elena Kuznetsova, Daria Int J Mol Sci Review Liver regeneration has been studied for many decades, and the mechanisms underlying regeneration of normal liver following resection are well described. However, no less relevant is the study of mechanisms that disrupt the process of liver regeneration. First of all, a violation of liver regeneration can occur in the presence of concomitant hepatic pathology, which is a key factor reducing the liver’s regenerative potential. Understanding these mechanisms could enable the rational targeting of specific therapies to either reduce the factors inhibiting regeneration or to directly stimulate liver regeneration. This review describes the known mechanisms of normal liver regeneration and factors that reduce its regenerative potential, primarily at the level of hepatocyte metabolism, in the presence of concomitant hepatic pathology. We also briefly discuss promising strategies for stimulating liver regeneration and those concerning methods for assessing the regenerative potential of the liver, especially intraoperatively. MDPI 2023-05-23 /pmc/articles/PMC10252688/ /pubmed/37298064 http://dx.doi.org/10.3390/ijms24119112 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rodimova, Svetlana
Mozherov, Artem
Elagin, Vadim
Karabut, Maria
Shchechkin, Ilya
Kozlov, Dmitry
Krylov, Dmitry
Gavrina, Alena
Bobrov, Nikolai
Zagainov, Vladimir
Zagaynova, Elena
Kuznetsova, Daria
Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration
title Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration
title_full Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration
title_fullStr Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration
title_full_unstemmed Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration
title_short Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration
title_sort effect of hepatic pathology on liver regeneration: the main metabolic mechanisms causing impaired hepatic regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252688/
https://www.ncbi.nlm.nih.gov/pubmed/37298064
http://dx.doi.org/10.3390/ijms24119112
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