Cargando…

GM1 Ganglioside as a Disease-Modifying Therapeutic for Parkinson’s Disease: A Multi-Functional Glycosphingolipid That Targets Multiple Parkinson’s Disease-Relevant Pathogenic Mechanisms

Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting millions of patients worldwide. Many therapeutics are available for treating PD symptoms but there is no disease-modifying therapeutic that has been unequivocally shown to slow or stop the progression of the disease. Ther...

Descripción completa

Detalles Bibliográficos
Autor principal:	Schneider, Jay S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252733/ https://www.ncbi.nlm.nih.gov/pubmed/37298133 http://dx.doi.org/10.3390/ijms24119183

Ejemplares similares

The Key Role of GM1 Ganglioside in Parkinson’s Disease
por: Chowdhury, Suman, et al.
Publicado: (2022)

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson’s Disease
por: Schneider, Jay S., et al.
Publicado: (2019)

Glycosphingolipids and neuroinflammation in Parkinson’s disease
por: Belarbi, Karim, et al.
Publicado: (2020)

The relationship between depletion of brain GM1 ganglioside and Parkinson's disease
por: Sonnino, Sandro
Publicado: (2023)

CREB5 hypermethylation involved in the ganglioside GM1 therapy of Parkinson’s disease
por: Wang, Rui, et al.
Publicado: (2023)

Intraventricular Sialidase Administration Enhances GM1 Ganglioside Expression and Is Partially Neuroprotective in a Mouse Model of Parkinson’s Disease
por: Schneider, Jay S., et al.
Publicado: (2015)

Systemic deficiency of GM1 ganglioside in Parkinson’s disease tissues and its relation to the disease etiology
por: Ledeen, Robert, et al.
Publicado: (2022)

Corrigendum: CREB5 hypermethylation involved in the ganglioside GM1 therapy of Parkinson's disease
por: Wang, Rui, et al.
Publicado: (2023)

Ganglioside Metabolism and Parkinson's Disease
por: Forsayeth, John, et al.
Publicado: (2018)

Disease‐modifying effects of ganglioside GM1 in Huntington's disease models
por: Alpaugh, Melanie, et al.
Publicado: (2017)

Glycosphingolipid metabolism and its role in ageing and Parkinson’s disease
por: Wallom, Kerri-Lee, et al.
Publicado: (2021)

Altered expression of genes involved in ganglioside biosynthesis in substantia nigra neurons in Parkinson’s disease
por: Schneider, Jay S.
Publicado: (2018)

Glycosphingolipid Changes in Plasma in Parkinson's Disease Independent of Glucosylceramide Levels
por: te Vruchte, Danielle, et al.
Publicado: (2022)

The cytoprotective role of GM1 ganglioside in Huntington disease cells
por: Hart, Hannah S., et al.
Publicado: (2022)

Pathophysiology of Ganglioside GM1 in Ischemic Stroke: Ganglioside GM1: A Critical Review
por: Zhang, Wenchao, et al.
Publicado: (2019)

Ganglioside GM1 promotes contact inhibition of growth by regulating the localization of epidermal growth factor receptor from glycosphingolipid‐enriched microdomain to caveolae
por: Zhuo, Dinghao, et al.
Publicado: (2019)

Age-Related Decline in Gangliosides GM1 and GD1a in Non-CNS Tissues of Normal Mice: Implications for Peripheral Symptoms of Parkinson’s Disease
por: Chowdhury, Suman, et al.
Publicado: (2023)

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease
por: Huebecker, Mylene, et al.
Publicado: (2019)

Mitophagy in Parkinson’s Disease: Pathogenic and Therapeutic Implications
por: Gao, Fei, et al.
Publicado: (2017)

Lyso-GM2 Ganglioside: A Possible Biomarker of Tay-Sachs Disease and Sandhoff Disease
por: Kodama, Takashi, et al.
Publicado: (2011)

Correction to: Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease
por: Huebecker, Mylene, et al.
Publicado: (2020)

Effect of Ganglioside combined with pramexol in the treatment of Parkinson's disease and its effect on motor function
por: Li, Xinna, et al.
Publicado: (2023)

Glycosphingolipid GM3 is Indispensable for Dengue Virus Genome Replication
por: Wang, Kezhen, et al.
Publicado: (2016)

The Glycosphingolipid GM3 Modulates Conformational Dynamics of the Glucagon Receptor
por: Ansell, T. Bertie, et al.
Publicado: (2020)

Gangliosides: Treatment Avenues in Neurodegenerative Disease
por: Magistretti, Pierre J., et al.
Publicado: (2019)

Ganglioside GM3 Levels Are Altered in a Mouse Model of HIBM: GM3 as a Cellular Marker of the Disease
por: Paccalet, Thomas, et al.
Publicado: (2010)

Pathogenic Aspects and Therapeutic Avenues of Autophagy in Parkinson’s Disease
por: Kinet, Rémi, et al.
Publicado: (2023)

Physiopathological function of hematoside (GM3 ganglioside)
por: INOKUCHI, Jin-ichi
Publicado: (2011)

Secondary ganglioside GM2 accumulation in mucopolysaccharidoses
por: Sandhoff, Konrad
Publicado: (2021)

Ganglioside GM1 and the Central Nervous System
por: Guo, Zhongwu
Publicado: (2023)

Biomarker candidates of neurodegeneration in Parkinson’s disease for the evaluation of disease-modifying therapeutics
por: Gerlach, Manfred, et al.
Publicado: (2011)

Subnormal GM1 in PBMCs: Promise for Early Diagnosis of Parkinson’s Disease?
por: Alselehdar, Samar K., et al.
Publicado: (2021)

Novel insights on GM1 and Parkinson's disease: A critical review
por: Fazzari, Maria, et al.
Publicado: (2022)

GM1 Oligosaccharide Efficacy in Parkinson’s Disease: Protection against MPTP
por: Fazzari, Maria, et al.
Publicado: (2023)

Glucocerebrosidase and its relevance to Parkinson disease
por: Do, Jenny, et al.
Publicado: (2019)

Elevation of gangliosides in four brain regions from Parkinson’s disease patients with a GBA mutation
por: Blumenreich, Shani, et al.
Publicado: (2022)

Mice Lacking Major Brain Gangliosides Develop Parkinsonism
por: Wu, Gusheng, et al.
Publicado: (2011)

Enhanced Levels of Glycosphingolipid GM3 Delay the Progression of Diabetic Nephropathy
por: Naito, Shokichi, et al.
Publicado: (2023)

Ganglioside GM3 Is Antiangiogenic in Malignant Brain Cancer
por: Seyfried, Thomas N., et al.
Publicado: (2010)

GM1 ganglioside-independent intoxication by Cholera toxin
por: Cervin, Jakob, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bsb9db0jnogodinjjh3d8f7q4i