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Chelator PBT2 Forms a Ternary Cu(2+) Complex with β-Amyloid That Has High Stability but Low Specificity
The metal chelator PBT2 (5,7-dichloro-2-[(dimethylamino)methyl]-8-hydroxyquinoline) acts as a terdentate ligand capable of forming binary and ternary Cu(2+) complexes. It was clinically trialed as an Alzheimer’s disease (AD) therapy but failed to progress beyond phase II. The β-amyloid (Aβ) peptide...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252752/ https://www.ncbi.nlm.nih.gov/pubmed/37298218 http://dx.doi.org/10.3390/ijms24119267 |