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Diabetic Neuropathy of the Retina and Inflammation: Perspectives
A clear connection exists between diabetes and atherosclerotic cardiovascular disease. Consequently, therapeutic approaches that target both diseases are needed. Clinical trials are currently underway to explore the roles of obesity, adipose tissue, gut microbiota, and pancreatic beta cell function...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252894/ https://www.ncbi.nlm.nih.gov/pubmed/37298118 http://dx.doi.org/10.3390/ijms24119166 |
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author | Bikbova, Guzel Oshitari, Toshiyuki Bikbov, Mukharram |
author_facet | Bikbova, Guzel Oshitari, Toshiyuki Bikbov, Mukharram |
author_sort | Bikbova, Guzel |
collection | PubMed |
description | A clear connection exists between diabetes and atherosclerotic cardiovascular disease. Consequently, therapeutic approaches that target both diseases are needed. Clinical trials are currently underway to explore the roles of obesity, adipose tissue, gut microbiota, and pancreatic beta cell function in diabetes. Inflammation plays a key role in diabetes pathophysiology and associated metabolic disorders; thus, interest has increased in targeting inflammation to prevent and control diabetes. Diabetic retinopathy is known as a neurodegenerative and vascular disease that occurs after some years of poorly controlled diabetes. However, increasing evidence points to inflammation as a key figure in diabetes-associated retinal complications. Interconnected molecular pathways, such as oxidative stress, and the formation of advanced glycation end-products, are known to contribute to the inflammatory response. This review describes the possible mechanisms of the metabolic changes in diabetes that involve inflammatory pathways. |
format | Online Article Text |
id | pubmed-10252894 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102528942023-06-10 Diabetic Neuropathy of the Retina and Inflammation: Perspectives Bikbova, Guzel Oshitari, Toshiyuki Bikbov, Mukharram Int J Mol Sci Review A clear connection exists between diabetes and atherosclerotic cardiovascular disease. Consequently, therapeutic approaches that target both diseases are needed. Clinical trials are currently underway to explore the roles of obesity, adipose tissue, gut microbiota, and pancreatic beta cell function in diabetes. Inflammation plays a key role in diabetes pathophysiology and associated metabolic disorders; thus, interest has increased in targeting inflammation to prevent and control diabetes. Diabetic retinopathy is known as a neurodegenerative and vascular disease that occurs after some years of poorly controlled diabetes. However, increasing evidence points to inflammation as a key figure in diabetes-associated retinal complications. Interconnected molecular pathways, such as oxidative stress, and the formation of advanced glycation end-products, are known to contribute to the inflammatory response. This review describes the possible mechanisms of the metabolic changes in diabetes that involve inflammatory pathways. MDPI 2023-05-23 /pmc/articles/PMC10252894/ /pubmed/37298118 http://dx.doi.org/10.3390/ijms24119166 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bikbova, Guzel Oshitari, Toshiyuki Bikbov, Mukharram Diabetic Neuropathy of the Retina and Inflammation: Perspectives |
title | Diabetic Neuropathy of the Retina and Inflammation: Perspectives |
title_full | Diabetic Neuropathy of the Retina and Inflammation: Perspectives |
title_fullStr | Diabetic Neuropathy of the Retina and Inflammation: Perspectives |
title_full_unstemmed | Diabetic Neuropathy of the Retina and Inflammation: Perspectives |
title_short | Diabetic Neuropathy of the Retina and Inflammation: Perspectives |
title_sort | diabetic neuropathy of the retina and inflammation: perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252894/ https://www.ncbi.nlm.nih.gov/pubmed/37298118 http://dx.doi.org/10.3390/ijms24119166 |
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