Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?

Accumulating evidence suggests that Interleukin-33 (IL-33), a member of the IL-1 family, has crucial roles in tissue homeostasis and repair, type 2 immunity, inflammation, and viral infection. IL-33 is a novel contributing factor in tumorigenesis and plays a critical role in regulating angiogenesis...

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Detalles Bibliográficos
Autores principales: Pisani, Laura Francesca, Teani, Isabella, Vecchi, Maurizio, Pastorelli, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252908/
https://www.ncbi.nlm.nih.gov/pubmed/37296602
http://dx.doi.org/10.3390/cells12111481
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author Pisani, Laura Francesca
Teani, Isabella
Vecchi, Maurizio
Pastorelli, Luca
author_facet Pisani, Laura Francesca
Teani, Isabella
Vecchi, Maurizio
Pastorelli, Luca
author_sort Pisani, Laura Francesca
collection PubMed
description Accumulating evidence suggests that Interleukin-33 (IL-33), a member of the IL-1 family, has crucial roles in tissue homeostasis and repair, type 2 immunity, inflammation, and viral infection. IL-33 is a novel contributing factor in tumorigenesis and plays a critical role in regulating angiogenesis and cancer progression in a variety of human cancers. The partially unraveled role of IL-33/ST2 signaling in gastrointestinal tract cancers is being investigated through the analysis of patients’ samples and by studies in murine and rat models. In this review, we discuss the basic biology and mechanisms of release of the IL-33 protein and its involvement in gastrointestinal cancer onset and progression.
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spelling pubmed-102529082023-06-10 Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers? Pisani, Laura Francesca Teani, Isabella Vecchi, Maurizio Pastorelli, Luca Cells Review Accumulating evidence suggests that Interleukin-33 (IL-33), a member of the IL-1 family, has crucial roles in tissue homeostasis and repair, type 2 immunity, inflammation, and viral infection. IL-33 is a novel contributing factor in tumorigenesis and plays a critical role in regulating angiogenesis and cancer progression in a variety of human cancers. The partially unraveled role of IL-33/ST2 signaling in gastrointestinal tract cancers is being investigated through the analysis of patients’ samples and by studies in murine and rat models. In this review, we discuss the basic biology and mechanisms of release of the IL-33 protein and its involvement in gastrointestinal cancer onset and progression. MDPI 2023-05-26 /pmc/articles/PMC10252908/ /pubmed/37296602 http://dx.doi.org/10.3390/cells12111481 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pisani, Laura Francesca
Teani, Isabella
Vecchi, Maurizio
Pastorelli, Luca
Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?
title Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?
title_full Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?
title_fullStr Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?
title_full_unstemmed Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?
title_short Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?
title_sort interleukin-33: friend or foe in gastrointestinal tract cancers?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252908/
https://www.ncbi.nlm.nih.gov/pubmed/37296602
http://dx.doi.org/10.3390/cells12111481
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AT teaniisabella interleukin33friendorfoeingastrointestinaltractcancers
AT vecchimaurizio interleukin33friendorfoeingastrointestinaltractcancers
AT pastorelliluca interleukin33friendorfoeingastrointestinaltractcancers

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