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Association Between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Meta-Analysis

OBJECTIVE: Recent epidemiological evidence shows that there is an association between serum uric acid (SUA) levels and nonalcoholic fatty liver disease (NAFLD). The purpose of this meta-analysis is to summarize all available evidence and assess the associations between SUA levels and NAFLD. METHODS:...

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Autores principales: Sun, Qianjia, Zhang, Tingjing, Manji, Laeeqa, Liu, Yashu, Chang, Qing, Zhao, Yuhong, Ding, Yang, Xia, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252946/
https://www.ncbi.nlm.nih.gov/pubmed/37305378
http://dx.doi.org/10.2147/CLEP.S403314
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author Sun, Qianjia
Zhang, Tingjing
Manji, Laeeqa
Liu, Yashu
Chang, Qing
Zhao, Yuhong
Ding, Yang
Xia, Yang
author_facet Sun, Qianjia
Zhang, Tingjing
Manji, Laeeqa
Liu, Yashu
Chang, Qing
Zhao, Yuhong
Ding, Yang
Xia, Yang
author_sort Sun, Qianjia
collection PubMed
description OBJECTIVE: Recent epidemiological evidence shows that there is an association between serum uric acid (SUA) levels and nonalcoholic fatty liver disease (NAFLD). The purpose of this meta-analysis is to summarize all available evidence and assess the associations between SUA levels and NAFLD. METHODS: Using two databases, Web of Science and PubMed, observational studies were applied from the establishment of the databases to June 2022. We used a random effect model to construct the pooled odds ratio (OR) and 95% confidence interval (CI) to appraise the association between SUA levels and NAFLD. The Begg’s test was conducted to appraise publication bias. RESULTS: A total of 50 studies were included, involving 2,079,710 participants (719,013 NAFLD patients). The prevalence and incidence rates (95% CIs) of NAFLD in the patients with hyperuricemia were 65% (57–73%) and 31% (20–41%), respectively. Compared to participants with lower levels of SUA, the pooled OR (95% CI) of NAFLD in those with higher levels of SUA was 1.88 (95% CI: 1.76–2.00). In the subgroup analyses, we found that SUA levels were positively associated with NAFLD in all subgroups, according to study design, study quality, sample size, sex, comparison, age, or country. CONCLUSION: This meta-analysis shows that increased SUA levels are positively associated with NAFLD. The results suggested that reducing SUA levels can be a potential strategy for the prevention of NAFLD. REGISTRATION NUMBER: PROSPERO-CRD42022358431.
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spelling pubmed-102529462023-06-10 Association Between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Meta-Analysis Sun, Qianjia Zhang, Tingjing Manji, Laeeqa Liu, Yashu Chang, Qing Zhao, Yuhong Ding, Yang Xia, Yang Clin Epidemiol Review OBJECTIVE: Recent epidemiological evidence shows that there is an association between serum uric acid (SUA) levels and nonalcoholic fatty liver disease (NAFLD). The purpose of this meta-analysis is to summarize all available evidence and assess the associations between SUA levels and NAFLD. METHODS: Using two databases, Web of Science and PubMed, observational studies were applied from the establishment of the databases to June 2022. We used a random effect model to construct the pooled odds ratio (OR) and 95% confidence interval (CI) to appraise the association between SUA levels and NAFLD. The Begg’s test was conducted to appraise publication bias. RESULTS: A total of 50 studies were included, involving 2,079,710 participants (719,013 NAFLD patients). The prevalence and incidence rates (95% CIs) of NAFLD in the patients with hyperuricemia were 65% (57–73%) and 31% (20–41%), respectively. Compared to participants with lower levels of SUA, the pooled OR (95% CI) of NAFLD in those with higher levels of SUA was 1.88 (95% CI: 1.76–2.00). In the subgroup analyses, we found that SUA levels were positively associated with NAFLD in all subgroups, according to study design, study quality, sample size, sex, comparison, age, or country. CONCLUSION: This meta-analysis shows that increased SUA levels are positively associated with NAFLD. The results suggested that reducing SUA levels can be a potential strategy for the prevention of NAFLD. REGISTRATION NUMBER: PROSPERO-CRD42022358431. Dove 2023-06-05 /pmc/articles/PMC10252946/ /pubmed/37305378 http://dx.doi.org/10.2147/CLEP.S403314 Text en © 2023 Sun et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Sun, Qianjia
Zhang, Tingjing
Manji, Laeeqa
Liu, Yashu
Chang, Qing
Zhao, Yuhong
Ding, Yang
Xia, Yang
Association Between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Meta-Analysis
title Association Between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Meta-Analysis
title_full Association Between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Meta-Analysis
title_fullStr Association Between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Meta-Analysis
title_full_unstemmed Association Between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Meta-Analysis
title_short Association Between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Meta-Analysis
title_sort association between serum uric acid and non-alcoholic fatty liver disease: an updated systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252946/
https://www.ncbi.nlm.nih.gov/pubmed/37305378
http://dx.doi.org/10.2147/CLEP.S403314
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