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The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review

The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood. The role of epigenetic factors is emphasized in the development of such diseases. MicroRNAs (miRNAs), a group of non-coding RNAs (ncRNAs—non-coding RNAs), are one of the important post-transcriptional epigene...

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Autores principales: Dopytalska, Klaudia, Czaplicka, Anna, Szymańska, Elżbieta, Walecka, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253000/
https://www.ncbi.nlm.nih.gov/pubmed/37298095
http://dx.doi.org/10.3390/ijms24119130
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author Dopytalska, Klaudia
Czaplicka, Anna
Szymańska, Elżbieta
Walecka, Irena
author_facet Dopytalska, Klaudia
Czaplicka, Anna
Szymańska, Elżbieta
Walecka, Irena
author_sort Dopytalska, Klaudia
collection PubMed
description The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood. The role of epigenetic factors is emphasized in the development of such diseases. MicroRNAs (miRNAs), a group of non-coding RNAs (ncRNAs—non-coding RNAs), are one of the important post-transcriptional epigenetic factors. miRNAs have a significant role in the regulation of the immune response by participating in the process of the differentiation and activation of B and T lymphocytes, macrophages, and dendritic cells. Recent advances in research on epigenetic factors have provided new insights into the pathogenesis and potential diagnostic and therapeutic targets of many pathologies. Numerous studies revealed a change in the expression of some microRNAs in inflammatory skin disorders, and the regulation of miRNA expression is a promising therapeutic goal. This review presents the state of the art regarding changes in the expression and role of miRNAs in inflammatory and autoimmune skin diseases, including psoriasis, atopic dermatitis, vitiligo, lichen planus, hidradenitis suppurativa, and autoimmune blistering diseases.
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spelling pubmed-102530002023-06-10 The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review Dopytalska, Klaudia Czaplicka, Anna Szymańska, Elżbieta Walecka, Irena Int J Mol Sci Review The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood. The role of epigenetic factors is emphasized in the development of such diseases. MicroRNAs (miRNAs), a group of non-coding RNAs (ncRNAs—non-coding RNAs), are one of the important post-transcriptional epigenetic factors. miRNAs have a significant role in the regulation of the immune response by participating in the process of the differentiation and activation of B and T lymphocytes, macrophages, and dendritic cells. Recent advances in research on epigenetic factors have provided new insights into the pathogenesis and potential diagnostic and therapeutic targets of many pathologies. Numerous studies revealed a change in the expression of some microRNAs in inflammatory skin disorders, and the regulation of miRNA expression is a promising therapeutic goal. This review presents the state of the art regarding changes in the expression and role of miRNAs in inflammatory and autoimmune skin diseases, including psoriasis, atopic dermatitis, vitiligo, lichen planus, hidradenitis suppurativa, and autoimmune blistering diseases. MDPI 2023-05-23 /pmc/articles/PMC10253000/ /pubmed/37298095 http://dx.doi.org/10.3390/ijms24119130 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dopytalska, Klaudia
Czaplicka, Anna
Szymańska, Elżbieta
Walecka, Irena
The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review
title The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review
title_full The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review
title_fullStr The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review
title_full_unstemmed The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review
title_short The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review
title_sort essential role of micrornas in inflammatory and autoimmune skin diseases—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253000/
https://www.ncbi.nlm.nih.gov/pubmed/37298095
http://dx.doi.org/10.3390/ijms24119130
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