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The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review
The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood. The role of epigenetic factors is emphasized in the development of such diseases. MicroRNAs (miRNAs), a group of non-coding RNAs (ncRNAs—non-coding RNAs), are one of the important post-transcriptional epigene...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253000/ https://www.ncbi.nlm.nih.gov/pubmed/37298095 http://dx.doi.org/10.3390/ijms24119130 |
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author | Dopytalska, Klaudia Czaplicka, Anna Szymańska, Elżbieta Walecka, Irena |
author_facet | Dopytalska, Klaudia Czaplicka, Anna Szymańska, Elżbieta Walecka, Irena |
author_sort | Dopytalska, Klaudia |
collection | PubMed |
description | The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood. The role of epigenetic factors is emphasized in the development of such diseases. MicroRNAs (miRNAs), a group of non-coding RNAs (ncRNAs—non-coding RNAs), are one of the important post-transcriptional epigenetic factors. miRNAs have a significant role in the regulation of the immune response by participating in the process of the differentiation and activation of B and T lymphocytes, macrophages, and dendritic cells. Recent advances in research on epigenetic factors have provided new insights into the pathogenesis and potential diagnostic and therapeutic targets of many pathologies. Numerous studies revealed a change in the expression of some microRNAs in inflammatory skin disorders, and the regulation of miRNA expression is a promising therapeutic goal. This review presents the state of the art regarding changes in the expression and role of miRNAs in inflammatory and autoimmune skin diseases, including psoriasis, atopic dermatitis, vitiligo, lichen planus, hidradenitis suppurativa, and autoimmune blistering diseases. |
format | Online Article Text |
id | pubmed-10253000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102530002023-06-10 The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review Dopytalska, Klaudia Czaplicka, Anna Szymańska, Elżbieta Walecka, Irena Int J Mol Sci Review The etiopathogenesis of autoimmune skin diseases is complex and still not fully understood. The role of epigenetic factors is emphasized in the development of such diseases. MicroRNAs (miRNAs), a group of non-coding RNAs (ncRNAs—non-coding RNAs), are one of the important post-transcriptional epigenetic factors. miRNAs have a significant role in the regulation of the immune response by participating in the process of the differentiation and activation of B and T lymphocytes, macrophages, and dendritic cells. Recent advances in research on epigenetic factors have provided new insights into the pathogenesis and potential diagnostic and therapeutic targets of many pathologies. Numerous studies revealed a change in the expression of some microRNAs in inflammatory skin disorders, and the regulation of miRNA expression is a promising therapeutic goal. This review presents the state of the art regarding changes in the expression and role of miRNAs in inflammatory and autoimmune skin diseases, including psoriasis, atopic dermatitis, vitiligo, lichen planus, hidradenitis suppurativa, and autoimmune blistering diseases. MDPI 2023-05-23 /pmc/articles/PMC10253000/ /pubmed/37298095 http://dx.doi.org/10.3390/ijms24119130 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dopytalska, Klaudia Czaplicka, Anna Szymańska, Elżbieta Walecka, Irena The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review |
title | The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review |
title_full | The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review |
title_fullStr | The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review |
title_full_unstemmed | The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review |
title_short | The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases—A Review |
title_sort | essential role of micrornas in inflammatory and autoimmune skin diseases—a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253000/ https://www.ncbi.nlm.nih.gov/pubmed/37298095 http://dx.doi.org/10.3390/ijms24119130 |
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