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Reliability of Multiparametric Magnetic Resonance Imaging in Patients with a Previous Negative Biopsy: Comparison with Biopsy-Naïve Patients in the Detection of Clinically Significant Prostate Cancer

Background: Multiparametric magnetic resonance is an established imaging utilized in the diagnostic pathway of prostate cancer. The aim of this study is to evaluate the accuracy and reliability of multiparametric magnetic resonance imaging (mpMRI) in the detection of clinically significant prostate...

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Autores principales: Barone, Biagio, Napolitano, Luigi, Calace, Francesco Paolo, Del Biondo, Dario, Napodano, Giorgio, Grillo, Marco, Reccia, Pasquale, De Luca, Luigi, Prezioso, Domenico, Muto, Matteo, Crocetto, Felice, Ferro, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253019/
https://www.ncbi.nlm.nih.gov/pubmed/37296791
http://dx.doi.org/10.3390/diagnostics13111939
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author Barone, Biagio
Napolitano, Luigi
Calace, Francesco Paolo
Del Biondo, Dario
Napodano, Giorgio
Grillo, Marco
Reccia, Pasquale
De Luca, Luigi
Prezioso, Domenico
Muto, Matteo
Crocetto, Felice
Ferro, Matteo
author_facet Barone, Biagio
Napolitano, Luigi
Calace, Francesco Paolo
Del Biondo, Dario
Napodano, Giorgio
Grillo, Marco
Reccia, Pasquale
De Luca, Luigi
Prezioso, Domenico
Muto, Matteo
Crocetto, Felice
Ferro, Matteo
author_sort Barone, Biagio
collection PubMed
description Background: Multiparametric magnetic resonance is an established imaging utilized in the diagnostic pathway of prostate cancer. The aim of this study is to evaluate the accuracy and reliability of multiparametric magnetic resonance imaging (mpMRI) in the detection of clinically significant prostate cancer, defined as Gleason Score ≥ 4 + 3 or a maximum cancer core length 6 mm or longer, in patients with a previous negative biopsy. Methods: The study was conducted as a retrospective observational study at the University of Naples “Federico II”, Italy. Overall, 389 patients who underwent systematic and target prostate biopsy between January 2019 and July 2020 were involved and were divided into two groups: Group A, which included biopsy-naïve patients; Group B, which included re-biopsy patients. All mpMRI images were obtained using three Tesla instruments and were interpreted according to PIRADS (Prostate Imaging Reporting and Data System) version 2.0. Results: 327 patients were biopsy-naïve, while 62 belonged to the re-biopsy group. Both groups were comparable in terms of age, total PSA (prostate-specific antigen), and number of cores obtained at the biopsy. 2.2%, 8.8%, 36.1%, and 83.4% of, respectively, PIRADS 2, 3, 4, and 5 biopsy-naïve patients reported a clinically significant prostate cancer compared to 0%, 14.3%, 39%, and 66.6% of re-biopsy patients (p < 0.0001–p = 0.040). No difference was reported in terms of post-biopsy complications. Conclusions: mpMRI confirms its role as a reliable diagnostic tool prior to performing prostate biopsy in patients who underwent a previous negative biopsy, reporting a comparable detection rate of clinically significant prostate cancer.
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spelling pubmed-102530192023-06-10 Reliability of Multiparametric Magnetic Resonance Imaging in Patients with a Previous Negative Biopsy: Comparison with Biopsy-Naïve Patients in the Detection of Clinically Significant Prostate Cancer Barone, Biagio Napolitano, Luigi Calace, Francesco Paolo Del Biondo, Dario Napodano, Giorgio Grillo, Marco Reccia, Pasquale De Luca, Luigi Prezioso, Domenico Muto, Matteo Crocetto, Felice Ferro, Matteo Diagnostics (Basel) Article Background: Multiparametric magnetic resonance is an established imaging utilized in the diagnostic pathway of prostate cancer. The aim of this study is to evaluate the accuracy and reliability of multiparametric magnetic resonance imaging (mpMRI) in the detection of clinically significant prostate cancer, defined as Gleason Score ≥ 4 + 3 or a maximum cancer core length 6 mm or longer, in patients with a previous negative biopsy. Methods: The study was conducted as a retrospective observational study at the University of Naples “Federico II”, Italy. Overall, 389 patients who underwent systematic and target prostate biopsy between January 2019 and July 2020 were involved and were divided into two groups: Group A, which included biopsy-naïve patients; Group B, which included re-biopsy patients. All mpMRI images were obtained using three Tesla instruments and were interpreted according to PIRADS (Prostate Imaging Reporting and Data System) version 2.0. Results: 327 patients were biopsy-naïve, while 62 belonged to the re-biopsy group. Both groups were comparable in terms of age, total PSA (prostate-specific antigen), and number of cores obtained at the biopsy. 2.2%, 8.8%, 36.1%, and 83.4% of, respectively, PIRADS 2, 3, 4, and 5 biopsy-naïve patients reported a clinically significant prostate cancer compared to 0%, 14.3%, 39%, and 66.6% of re-biopsy patients (p < 0.0001–p = 0.040). No difference was reported in terms of post-biopsy complications. Conclusions: mpMRI confirms its role as a reliable diagnostic tool prior to performing prostate biopsy in patients who underwent a previous negative biopsy, reporting a comparable detection rate of clinically significant prostate cancer. MDPI 2023-06-01 /pmc/articles/PMC10253019/ /pubmed/37296791 http://dx.doi.org/10.3390/diagnostics13111939 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barone, Biagio
Napolitano, Luigi
Calace, Francesco Paolo
Del Biondo, Dario
Napodano, Giorgio
Grillo, Marco
Reccia, Pasquale
De Luca, Luigi
Prezioso, Domenico
Muto, Matteo
Crocetto, Felice
Ferro, Matteo
Reliability of Multiparametric Magnetic Resonance Imaging in Patients with a Previous Negative Biopsy: Comparison with Biopsy-Naïve Patients in the Detection of Clinically Significant Prostate Cancer
title Reliability of Multiparametric Magnetic Resonance Imaging in Patients with a Previous Negative Biopsy: Comparison with Biopsy-Naïve Patients in the Detection of Clinically Significant Prostate Cancer
title_full Reliability of Multiparametric Magnetic Resonance Imaging in Patients with a Previous Negative Biopsy: Comparison with Biopsy-Naïve Patients in the Detection of Clinically Significant Prostate Cancer
title_fullStr Reliability of Multiparametric Magnetic Resonance Imaging in Patients with a Previous Negative Biopsy: Comparison with Biopsy-Naïve Patients in the Detection of Clinically Significant Prostate Cancer
title_full_unstemmed Reliability of Multiparametric Magnetic Resonance Imaging in Patients with a Previous Negative Biopsy: Comparison with Biopsy-Naïve Patients in the Detection of Clinically Significant Prostate Cancer
title_short Reliability of Multiparametric Magnetic Resonance Imaging in Patients with a Previous Negative Biopsy: Comparison with Biopsy-Naïve Patients in the Detection of Clinically Significant Prostate Cancer
title_sort reliability of multiparametric magnetic resonance imaging in patients with a previous negative biopsy: comparison with biopsy-naïve patients in the detection of clinically significant prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253019/
https://www.ncbi.nlm.nih.gov/pubmed/37296791
http://dx.doi.org/10.3390/diagnostics13111939
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