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Genetic Ablation of LAT1 Inhibits Growth of Liver Cancer Cells and Downregulates mTORC1 Signaling

Through a comprehensive analysis of the gene expression and dependency in HCC patients and cell lines, LAT1 was identified as the top amino acid transporter candidate supporting HCC tumorigenesis. To assess the suitability of LAT1 as a HCC therapeutic target, we used CRISPR/Cas9 to knockout (KO) LAT...

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Detalles Bibliográficos
Autores principales:	Kim, Sun-Yee, Ong, Qunxiang, Liao, Yilie, Ding, Zhaobing, Tan, Alicia Qian Ler, Lim, Ler Ting Rachel, Tan, Hui Min, Lim, Siew Lan, Lee, Qian Yi, Han, Weiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253063/ https://www.ncbi.nlm.nih.gov/pubmed/37298123 http://dx.doi.org/10.3390/ijms24119171

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