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New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan

Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is an important enzyme in the DNA repair system. The ability of the enzyme to repair DNA damage induced by a topoisomerase 1 poison such as the anticancer drug topotecan makes TDP1 a promising target for complex antitumor therapy. In this work, a set of new 5-h...

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Detalles Bibliográficos
Autores principales:	Khomenko, Tatyana M., Zakharenko, Alexandra L., Kornienko, Tatyana E., Chepanova, Arina A., Dyrkheeva, Nadezhda S., Artemova, Anastasia O., Korchagina, Dina V., Achara, Chigozie, Curtis, Anthony, Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253161/ https://www.ncbi.nlm.nih.gov/pubmed/37298106 http://dx.doi.org/10.3390/ijms24119155

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