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The Emerging Roles of the Adaptive Immune Response in Acute Pancreatitis

Acute pancreatitis (AP) is an abrupt, variable inflammatory condition of the pancreas, potentially escalating to severe systemic inflammation, rampant pancreatic necrosis, and multi-organ failure. Its complex pathogenesis involves an intricate immune response, with different T cell subsets (Th1, Th2...

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Autores principales: Stojanovic, Bojan, Jovanovic, Ivan P., Stojanovic, Milica Dimitrijevic, Jovanovic, Marina, Vekic, Berislav, Milosevic, Bojan, Cvetkovic, Aleksandar, Spasic, Marko, Stojanovic, Bojana S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253175/
https://www.ncbi.nlm.nih.gov/pubmed/37296616
http://dx.doi.org/10.3390/cells12111495
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author Stojanovic, Bojan
Jovanovic, Ivan P.
Stojanovic, Milica Dimitrijevic
Jovanovic, Marina
Vekic, Berislav
Milosevic, Bojan
Cvetkovic, Aleksandar
Spasic, Marko
Stojanovic, Bojana S.
author_facet Stojanovic, Bojan
Jovanovic, Ivan P.
Stojanovic, Milica Dimitrijevic
Jovanovic, Marina
Vekic, Berislav
Milosevic, Bojan
Cvetkovic, Aleksandar
Spasic, Marko
Stojanovic, Bojana S.
author_sort Stojanovic, Bojan
collection PubMed
description Acute pancreatitis (AP) is an abrupt, variable inflammatory condition of the pancreas, potentially escalating to severe systemic inflammation, rampant pancreatic necrosis, and multi-organ failure. Its complex pathogenesis involves an intricate immune response, with different T cell subsets (Th1, Th2, Th9, Th17, Th22, TFH, Treg, and CD8(+) T cells) and B cells playing pivotal roles. Early T cell activation initiates the AP development, triggering cytokines associated with the Th1 response, which stimulate macrophages and neutrophils. Other T cell phenotypes contribute to AP’s pathogenesis, and the balance between pro-inflammatory and anti-inflammatory cytokines influences its progression. Regulatory T and B cells are crucial for moderating the inflammatory response and promoting immune tolerance. B cells further contribute through antibody production, antigen presentation, and cytokine secretion. Understanding these immune cells’ roles in AP could aid in developing new immunotherapies to enhance patient outcomes. However, further research is required to define these cells’ precise roles in AP and their potential as therapeutic targets.
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spelling pubmed-102531752023-06-10 The Emerging Roles of the Adaptive Immune Response in Acute Pancreatitis Stojanovic, Bojan Jovanovic, Ivan P. Stojanovic, Milica Dimitrijevic Jovanovic, Marina Vekic, Berislav Milosevic, Bojan Cvetkovic, Aleksandar Spasic, Marko Stojanovic, Bojana S. Cells Review Acute pancreatitis (AP) is an abrupt, variable inflammatory condition of the pancreas, potentially escalating to severe systemic inflammation, rampant pancreatic necrosis, and multi-organ failure. Its complex pathogenesis involves an intricate immune response, with different T cell subsets (Th1, Th2, Th9, Th17, Th22, TFH, Treg, and CD8(+) T cells) and B cells playing pivotal roles. Early T cell activation initiates the AP development, triggering cytokines associated with the Th1 response, which stimulate macrophages and neutrophils. Other T cell phenotypes contribute to AP’s pathogenesis, and the balance between pro-inflammatory and anti-inflammatory cytokines influences its progression. Regulatory T and B cells are crucial for moderating the inflammatory response and promoting immune tolerance. B cells further contribute through antibody production, antigen presentation, and cytokine secretion. Understanding these immune cells’ roles in AP could aid in developing new immunotherapies to enhance patient outcomes. However, further research is required to define these cells’ precise roles in AP and their potential as therapeutic targets. MDPI 2023-05-29 /pmc/articles/PMC10253175/ /pubmed/37296616 http://dx.doi.org/10.3390/cells12111495 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stojanovic, Bojan
Jovanovic, Ivan P.
Stojanovic, Milica Dimitrijevic
Jovanovic, Marina
Vekic, Berislav
Milosevic, Bojan
Cvetkovic, Aleksandar
Spasic, Marko
Stojanovic, Bojana S.
The Emerging Roles of the Adaptive Immune Response in Acute Pancreatitis
title The Emerging Roles of the Adaptive Immune Response in Acute Pancreatitis
title_full The Emerging Roles of the Adaptive Immune Response in Acute Pancreatitis
title_fullStr The Emerging Roles of the Adaptive Immune Response in Acute Pancreatitis
title_full_unstemmed The Emerging Roles of the Adaptive Immune Response in Acute Pancreatitis
title_short The Emerging Roles of the Adaptive Immune Response in Acute Pancreatitis
title_sort emerging roles of the adaptive immune response in acute pancreatitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253175/
https://www.ncbi.nlm.nih.gov/pubmed/37296616
http://dx.doi.org/10.3390/cells12111495
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