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Inducible and Conditional Activation of Adult Neurogenesis Rescues Cadmium-Induced Hippocampus-Dependent Memory Deficits in ApoE4-KI Mice

The apolipoprotein E (ApoE) gene is a genetic risk factor for late-onset Alzheimer’s disease, in which ε4 allele carriers have increased risk compared to the common ε3 carriers. Cadmium (Cd) is a toxic heavy metal and a potential neurotoxicant. We previously reported a gene–environment interaction (...

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Detalles Bibliográficos
Autores principales: Matsushita, Megumi T., Wang, Hao, Abel, Glen M., Xia, Zhengui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253189/
https://www.ncbi.nlm.nih.gov/pubmed/37298071
http://dx.doi.org/10.3390/ijms24119118